Dalby Tine, Harboe Zitta B, Krogfelt Karen Angeliki
Department of Microbiologic Surveillance and Research, Statens Serum Institut, Artillerivej 5, 45-305, DK-2300 Copenhagen S, Denmark.
Clin Vaccine Immunol. 2010 Dec;17(12):2016-23. doi: 10.1128/CVI.00270-10. Epub 2010 Oct 6.
The common perception that pertussis is only a childhood disease is not correct. Vaccination or infection with Bordetella pertussis provides only short-lived protection against pertussis-and the majority of the population is consequently at risk of contracting pertussis. We evaluated the seroprevalence of pertussis antibodies (IgG against pertussis toxin) in serum samples from 265 Danish patients, aged 8 years and older, with coughs of unknown etiology. Depending on the cutoff chosen, we found that 2.6% to 10.9% of these patients were seropositive for pertussis. Of 178 patients with a reported duration of cough between 2 weeks and 3 months, 3.4% to 12.4% were seropositive for pertussis, indicating recent infection. Our study indicates that B. pertussis infection may be underdiagnosed among older children and adults with coughs in Denmark.
认为百日咳只是一种儿童疾病的普遍看法是不正确的。接种疫苗或感染百日咳博德特氏菌只能提供短期的百日咳免疫力，因此大多数人都有感染百日咳的风险。我们评估了265名年龄在8岁及以上、病因不明咳嗽的丹麦患者血清样本中百日咳抗体（抗百日咳毒素IgG）的血清阳性率。根据所选的临界值，我们发现这些患者中有2.6%至10.9%百日咳血清呈阳性。在报告咳嗽持续时间为2周零3个月的178名患者中，3.4%至12.4%百日咳血清呈阳性，表明近期感染。我们的研究表明，在丹麦，年龄较大的儿童和成人咳嗽患者中，百日咳博德特氏菌感染可能未得到充分诊断。
