Graakjaer Jesper, Der-Sarkissian Héra, Schmitz Annette, Bayer Jan, Thomas Gilles, Kolvraa Steen, Londoño-Vallejo José-Arturo
Telomeres and Cancer Lab, UMR7147, CNRS-I, Curie-UPMC, Paris, France.
Hum Genet. 2006 Apr;119(3):344-50. doi: 10.1007/s00439-006-0137-x. Epub 2006 Jan 27.
Previous studies have indicated that single relative telomere lengths are defined in the zygote. In order to explore the possibility that single telomere lengths segregate in families, we compared relative telomere lengths obtained from allelic chromosome extremities transmitted from parent to child, representing a total of 31 independent meiotic events. We find a significant positive correlation of 0.65 (P=0.0004) between these telomere lengths, whereas the correlation between the non-transmitted parental homologue and the transmitted homologue in the child is not statistically significant (r=0.16; P=0.195). This study indicates that, even though there is a telomerase-mediated maintenance/elongation of telomeres in germ cells, allele-specific relative telomere lengths are preserved in the next generation.
先前的研究表明，单个相对端粒长度在受精卵中就已确定。为了探究单个端粒长度在家族中分离的可能性，我们比较了从父母传递给子女的等位染色体末端获得的相对端粒长度，共代表31个独立的减数分裂事件。我们发现这些端粒长度之间存在显著的正相关，相关系数为0.65（P = 0.0004），而未传递的亲本同源染色体与子代中传递的同源染色体之间的相关性无统计学意义（r = 0.16；P = 0.195）。这项研究表明，尽管生殖细胞中端粒存在端粒酶介导的维持/延长，但等位基因特异性相对端粒长度在下一代中得以保留。
