Gill Matthew S
Buck Institute for Age Research, Novato, CA 94945, USA.
Aging Cell. 2006 Feb;5(1):23-30. doi: 10.1111/j.1474-9726.2006.00186.x.
Studies in the nematode Caenorhabditis elegans have been instrumental in defining genetic pathways that are involved in modulating lifespan. Multiple processes such as endocrine signaling, nutritional sensing and mitochondrial function play a role in determining lifespan in the worm and these mechanisms appear to be conserved across species. These discoveries have identified a range of novel targets for pharmacological manipulation of lifespan and it is likely that the nematode model will now prove useful in the discovery of compounds that slow aging. This review will focus on the endocrine targets for intervention in aging and the use of C. elegans as a system for high throughput screens of compounds for their effects on aging.
对线虫秀丽隐杆线虫的研究在确定参与调节寿命的遗传途径方面发挥了重要作用。内分泌信号传导、营养感知和线粒体功能等多种过程在决定线虫寿命方面发挥作用，并且这些机制似乎在物种间具有保守性。这些发现确定了一系列用于寿命药理学操纵的新靶点，并且线虫模型现在很可能将被证明在发现延缓衰老的化合物方面有用。本综述将聚焦于衰老干预的内分泌靶点以及将秀丽隐杆线虫用作化合物高通量筛选系统以研究其对衰老的影响。
