较高的红细胞（RBC）乳酸转运蛋白活性是否能解释镰状细胞性状中红细胞变形能力受损的现象？

Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?

作者信息

Connes Philippe, Sara Fagnété, Hardy-Dessources Marie-Dominique, Etienne-Julan Maryse, Hue Olivier

机构信息

EA 3596, Laboratoire ACTES, Université des Antilles et de la Guyane, Campus de Fouillole, 97159 Pointe-à-Pitre, Guadeloupe.

出版信息

Jpn J Physiol. 2005 Dec;55(6):385-7. doi: 10.2170/jjphysiol.S653. Epub 2006 Jan 31.

DOI:10.2170/jjphysiol.S653

PMID:16441976

Abstract

Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.

摘要

乳酸和氢离子被认为会促进含有血红蛋白S的红细胞（RBC）的镰变过程。我们发现，与对照受试者相比，镰状细胞性状（SCT）携带者的红细胞单羧酸转运体MCT-1活性更高，红细胞变形性更低，血液学指标受损，这表明MCT-1参与了SCT携带者的血液流变学紊乱。