Connes Philippe, Hue Olivier, Hardy-Dessources Marie-Dominique, Boucher John H, Pichot Vincent, Barthélémy Jean-Claude
EA 3596, Laboratoire ACTES, Département de Physiologie, Université des Antilles et de la Guyane, Campus de Fouillole, Pointe-à-Pitre, Guadeloupe.
Clin Hemorheol Microcirc. 2008;38(4):257-65.
The aim of the present study was to test the relationships between hemorheology and autonomic nervous system (ANS) activity in 23 sickle cell trait (SCT) carriers and 17 control subjects. Hemorheological parameters were assessed at rest. Nocturnal ANS activity was calculated from heart rate variability indices. Impairment was observed in both domains in SCT carriers as they showed higher blood viscosity, higher red blood cell rigidity and a lower index of oxygen supply to tissues, as well as lower ANS activity. The index of oxygen supply to tissues was positively correlated with some of the indices of parasympathetic activity and global ANS activity. Negative correlations were found between blood viscosity and the very low frequency of the spectrum (VLF) that contains partial parasympathetic activity and between red blood cell rigidity and the percentage of differences between adjacent normal RR intervals more than 50 ms (PNN50), which also describes parasympathetic activity. These results support the hypothesis that autonomic nervous system equilibrium is affected by perturbations in blood rheology. Mechanisms have yet to be elucidated.
本研究的目的是检测23名镰状细胞性状（SCT）携带者和17名对照受试者的血液流变学与自主神经系统（ANS）活动之间的关系。在静息状态下评估血液流变学参数。根据心率变异性指数计算夜间ANS活动。在SCT携带者的这两个方面均观察到损害，因为他们表现出血液粘度更高、红细胞刚性更高、组织氧供应指数更低，以及ANS活动更低。组织氧供应指数与副交感神经活动的一些指标和整体ANS活动呈正相关。血液粘度与包含部分副交感神经活动的频谱极低频（VLF）之间以及红细胞刚性与相邻正常RR间期差异超过50毫秒的百分比（PNN50，也描述副交感神经活动）之间存在负相关。这些结果支持自主神经系统平衡受血液流变学紊乱影响这一假说。其机制尚待阐明。
