测定离子钙、总钙及白蛋白校正钙用于诊断恶性肿瘤高钙血症。

Estimation of ionized calcium, total calcium and albumin corrected calcium for the diagnosis of hypercalcaemia of malignancy.

作者信息

Ijaz Aamir, Mehmood Tariq, Qureshi Ayaz Hussain, Anwar Masood, Dilawar Muhammad, Hussain Iftikhar, Khan Farooq Ahmad, Khan Dilshad Ahmad, Hussain Shujaat, Khan Iqbal Ahmad

机构信息

Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi.

出版信息

J Coll Physicians Surg Pak. 2006 Jan;16(1):49-52.

PMID:16441990

Abstract

OBJECTIVE

To measure levels of ionized calcium, total calcium and albumin corrected calcium in patients with different malignant disorders for the diagnosis of hypercalcaemia of malignancy.

DESIGN

A case control comparative study.

PLACE AND DURATION OF STUDY

The study was carried out in the Department of Pathology, Army Medical College Rawalpindi, Armed Forces Institute of Pathology and Department of Oncology CMH, Rawalpindi from March 2003 to December 2003.

SUBJECTS AND METHODS

Ninetyseven patients of various malignant disorders, admitted in the Department of Oncology, CMH, Rawalpindi, and 39 age and gender-matched disease-free persons (as control) were included in the study. Blood ionized calcium (Ca++), pH, sodium (Na+) and potassium (K+) were analysed by Ion selective electrode (ISE) on Easylyte auto analyser. Other related parameters were measured by colourimetric methods.

RESULTS

Blood Ca(++) levels in patients suffering from malignant disorders were found significantly high (mean +/- SD: 1.30+017 mmol/L) as compared to control subjects (mean +/- SD 1.23+0.03 mmol/L) (p<0.001). The number of patients with hypercalcaemia of malignancy detected by Ca(++) estimation was significantly higher (38%) as compared to total calcium (8.4%) and albumin corrected calcium ACC (10.6%) (p<0.001). There was no statistically significant difference in other parameters e.g. phosphate, urea, creatinine, pH, Na+ and K+ levels in study subjects and controls.

CONCLUSION

Detection of hypercalcaemia can be markedly improved if ionized calcium estimation is used in patients with malignant disorders.

摘要

目的

检测不同恶性疾病患者的离子钙、总钙及白蛋白校正钙水平，以诊断恶性肿瘤高钙血症。

设计

病例对照比较研究。

研究地点及时间

本研究于2003年3月至2003年12月在拉瓦尔品第陆军医学院病理科、武装部队病理研究所及拉瓦尔品第CMH肿瘤内科进行。

研究对象与方法

纳入拉瓦尔品第CMH肿瘤内科收治的97例各种恶性疾病患者，以及39例年龄和性别匹配的无病者（作为对照）。采用离子选择电极（ISE）在Easylyte自动分析仪上分析血离子钙（Ca++）、pH、钠（Na+）和钾（K+）。其他相关参数采用比色法测量。

结果

与对照组相比，恶性疾病患者的血Ca(++)水平显著升高（均值±标准差：1.30 + 0.17 mmol/L）（对照组均值±标准差为1.23 + 0.03 mmol/L）（p < 0.001）。通过Ca(++)测定检测出的恶性肿瘤高钙血症患者数量显著高于总钙（8.4%）和白蛋白校正钙ACC（10.6%）（p < 0.001）。研究对象与对照组在其他参数如磷酸盐、尿素、肌酐、pH、Na+和K+水平上无统计学显著差异。