Baba Mete, Bal Nebil
Department of Dermatology and Pathology, Faculty of Medicine, Baskent University, Adana Hospital, Adana, Turkey.
Dermatol Surg. 2006 Feb;32(2):256-60. doi: 10.1111/j.1524-4725.2006.32043.x.
Various laser systems have been used in the treatment of acquired melanocytic nevi. However, CO2 lasers may cause scarring, and some nevi cannot be removed with pigment-specific lasers completely. To date, no study has evaluated the efficacy and safety of an erbium:yttrium-aluminum-garnet (YAG) laser, with its small penetration depth and fewer adverse effects, in the treatment of acquired melanocytic nevi.
To investigate the efficacy and safety of the short-pulse erbium:YAG laser in the treatment of acquired melanocytic nevi.
The study included 28 nevi in 14 patients. The lesions were pigmented, flat, or just palpable nevi. Nevi were irradiated with single-pulse laser energy of 1,000 mJ and a pulse duration of 300 microseconds. Fluences between 5.2 and 14.4 J/cm2 were used. Four months following laser treatment, the entire lesion was excised. Each specimen was histopathologically and immunohistochemically examined for the presence of nevus cells.
Clinically, all of the nevi and, histopathologically, 27 of 28 nevi (96%) were completely removed without scarring. Post-inflammatory hyperpigmentation was seen in two patients and hypopigmentation in three patients.
Short-pulse erbium:YAG laser treatment is an effective and safe method for removing acquired melanocytic nevi.
各种激光系统已被用于治疗后天性黑素细胞痣。然而，二氧化碳激光可能会导致瘢痕形成，并且一些痣不能用特定色素激光完全去除。迄今为止，尚无研究评估掺铒钇铝石榴石（YAG）激光因其穿透深度小且不良反应较少，在治疗后天性黑素细胞痣方面的疗效和安全性。
探讨短脉冲掺铒YAG激光治疗后天性黑素细胞痣的疗效和安全性。
该研究纳入了14例患者的28颗痣。这些病变为色素沉着、扁平或仅可触及的痣。用1000 mJ的单脉冲激光能量和300微秒的脉冲持续时间对痣进行照射。使用的能量密度在5.2至14.4 J/cm²之间。激光治疗四个月后，将整个病变切除。对每个标本进行组织病理学和免疫组织化学检查以检测痣细胞的存在。
临床上，所有痣均被去除，组织病理学上，28颗痣中的27颗（96%）被完全去除且无瘢痕形成。两名患者出现炎症后色素沉着，三名患者出现色素减退。
短脉冲掺铒YAG激光治疗是去除后天性黑素细胞痣的一种有效且安全的方法。
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