亚慢性抗精神病药物治疗不会改变大鼠大脑磷脂脂肪酸组成。
Sub-chronic antipsychotic drug treatment does not alter brain phospholipid fatty acid composition in rats.
作者信息
Levant Beth, Crane Jennifer F, Carlson Susan E
机构信息
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jun;30(4):728-32. doi: 10.1016/j.pnpbp.2005.11.034. Epub 2006 Jan 24.
Altered membrane phospholipid fatty acid composition is reported in schizophrenia and appears to be reduced by antipsychotic drug treatment. To determine whether antipsychotic drugs have a direct effect on brain phospholipid fatty acid composition, the effects of sub-chronic treatment with a "typical" and an "atypical" antipsychotic drug were determined in adult male Sprague-Dawley rats. Rats were treated with haloperidol (1 mg/kg), clozapine (20 mg/kg) or vehicle daily for 21 days. Whole brain total phospholipid composition was determined by gas chromatography. No alterations in brain phospholipid composition were produced by either drug. This suggests that the apparent normalization of membrane phospholipids observed in drug-treated schizophrenic patients is not due to a direct pharmacological effect of these drugs nor can the pharmacological effects of these drugs occurring in this time frame be attributed to alterations in neuronal membrane fatty acid composition.
据报道，精神分裂症患者的膜磷脂脂肪酸组成发生改变，且抗精神病药物治疗似乎可使其降低。为确定抗精神病药物是否对脑磷脂脂肪酸组成有直接影响，研究了“典型”和“非典型”抗精神病药物亚慢性治疗对成年雄性斯普拉-道利大鼠的影响。大鼠每日接受氟哌啶醇（1毫克/千克）、氯氮平（20毫克/千克）或赋形剂治疗，持续21天。通过气相色谱法测定全脑总磷脂组成。两种药物均未引起脑磷脂组成的改变。这表明，在接受药物治疗的精神分裂症患者中观察到的膜磷脂明显正常化并非由于这些药物的直接药理作用，而且在此时间范围内这些药物的药理作用也不能归因于神经元膜脂肪酸组成的改变。
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