Guan Z, Wang Y, Xiao K
Guiyang Medical College.
Zhonghua Yi Xue Za Zhi. 1997 Aug;77(8):592-6.
To investigate the pathogenesis of brain damage by fluoride intoxication, phospholipid content, and fatty acid composition in rat brain with fluorosis were annlysed.
Wistar rats were fed with NaF in various amounts and time periods to produce the animal model with chronic fluorosis. Phospholipid content and fatty acids composition were analysed using high performance liquid chromatography and gas chromatography, respectively.
All animals fed with high amount of fluoride suffered from chronic fluorosis. The total brain phospholipid content was lower in the rat treated with fluoride, which mainly influenced phosphatidylethanolamine, phosphatidylcholin, and phosphatidylserine. No modifications were detected in fatty acid and aldehyde compositions of individual phospholipid classes.
The metabolism of brain phospholipid might be interfered by fluoride accumulated in brain tissue, which is related with the degeneration of neuron. The changes of brain phospholipid could be involved in the pathogenesis of chronic fluorosis.
为研究氟中毒致脑损伤的发病机制，分析氟中毒大鼠脑内磷脂含量及脂肪酸组成。
用不同剂量的氟化钠在不同时间段喂养Wistar大鼠，以建立慢性氟中毒动物模型。分别采用高效液相色谱法和气相色谱法分析磷脂含量和脂肪酸组成。
所有高氟喂养的动物均患慢性氟中毒。氟处理大鼠的脑总磷脂含量较低，主要影响磷脂酰乙醇胺、磷脂酰胆碱和磷脂酰丝氨酸。各磷脂类别的脂肪酸和醛组成未检测到变化。
脑组织中蓄积的氟可能干扰脑磷脂代谢，这与神经元变性有关。脑磷脂的变化可能参与慢性氟中毒的发病机制。
