Lamale Leah M, Lutgendorf Susan K, Hoffman Anna N, Kreder Karl J
Department of Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA.
Urology. 2006 Feb;67(2):242-5. doi: 10.1016/j.urology.2005.08.054. Epub 2006 Jan 25.
To examine the relationships between symptoms and cystoscopic findings in women newly diagnosed with interstitial cystitis who had not previously received treatment.
Twelve newly diagnosed and not previously treated women with interstitial cystitis completed a bladder symptom questionnaire the day before undergoing cystoscopy, hydrodistension, and biopsy. The daily voiding frequency was reported. Cystoscopic findings were converted to a numerical scale, and the data were analyzed using Pearson correlations.
Pain symptoms had consistent positive correlations with the cystoscopic findings. An increase in pain with bladder filling was associated with inflammation (P = 0.011), ulceration, and smaller bladder capacity. Pain relief after voiding correlated with smaller bladder capacity (P = 0.019), hematuria, and total cystoscopic score. Pain intensity in the urethra was related to ulceration and hematuria, and pain in the lower abdomen was related to a smaller bladder capacity (P = 0.047), glomerulations, and a larger total cystoscopic score. Daytime frequency correlated negatively with most cystoscopic findings, and nocturnal frequency had a positive relationship with most cystoscopic findings and was significantly associated with a smaller bladder capacity (P = 0.010). Urgency showed no strong associations with any cystoscopic findings.
In patients with untreated interstitial cystitis, a strong correlation between pain and cystoscopic findings was observed. The differences between our results and those of previous studies that found no relationship between symptom reports and cystoscopic findings suggest possible effects of treatment on pain perception and therapeutic influence on cystoscopic findings.
研究初诊且未接受过治疗的间质性膀胱炎女性患者的症状与膀胱镜检查结果之间的关系。
12例初诊且未接受过治疗的间质性膀胱炎女性患者在接受膀胱镜检查、膀胱水扩张及活检前一天完成膀胱症状问卷。记录每日排尿频率。膀胱镜检查结果转换为数字评分，数据采用Pearson相关性分析。
疼痛症状与膀胱镜检查结果呈一致的正相关。膀胱充盈时疼痛加剧与炎症（P = 0.011）、溃疡及膀胱容量较小有关。排尿后疼痛缓解与膀胱容量较小（P = 0.019）、血尿及膀胱镜检查总分有关。尿道疼痛强度与溃疡和血尿有关，下腹部疼痛与膀胱容量较小（P = 0.047）、膀胱黏膜下出血点及膀胱镜检查总分较高有关。白天排尿频率与大多数膀胱镜检查结果呈负相关，夜间排尿频率与大多数膀胱镜检查结果呈正相关，且与膀胱容量较小显著相关（P = 0.010）。尿急与任何膀胱镜检查结果均无明显关联。
在未经治疗的间质性膀胱炎患者中，观察到疼痛与膀胱镜检查结果之间存在强烈相关性。我们的结果与之前研究中症状报告与膀胱镜检查结果无关联的结果之间的差异表明，治疗可能对疼痛感知有影响，且对膀胱镜检查结果有治疗作用。
