Charles Christopher J, Rademaker Miriam T, Richards A Mark, Yandle Timothy G
Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.
Peptides. 2006 Jul;27(7):1801-5. doi: 10.1016/j.peptides.2005.12.010. Epub 2006 Jan 25.
Although urocortin 1 (Ucn-1) has been reported to circulate in human plasma and be raised in heart failure, little, if any, information is available regarding the source of circulating Ucn-1. Accordingly, we have performed trans-organ arteriovenous sampling for measurement of Ucn-1 concentration in anesthetized sheep before and after development of pacing-induced heart failure. Arterial plasma Ucn-1 levels measured 15.2 +/- 0.5 pmol/L in normal sheep and increased significantly following development of heart failure to 19.1 +/- 1.6 (p < 0.05). Small but significant positive arteriovenous gradients were observed across the hepatic and renal tissue beds in both states, with rises across the hind limb significant in normal animals and across the head in heart failure. This is the first report identifying sources of circulating Ucn-1.
虽然有报道称尿皮质素1（Ucn-1）存在于人体血浆中，且在心力衰竭时会升高，但关于循环Ucn-1的来源，即便有相关信息也非常少。因此，我们对麻醉的绵羊进行了跨器官动静脉采样，以测量起搏诱导的心力衰竭发生前后Ucn-1的浓度。正常绵羊动脉血浆Ucn-1水平为15.2±0.5 pmol/L，心力衰竭发生后显著升高至19.1±1.6（p<0.05）。在两种状态下，肝和肾组织床均观察到小而显著的正动静脉梯度，正常动物后肢的梯度升高显著，心力衰竭时头部的梯度升高显著。这是首次报道循环Ucn-1的来源。
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