尿皮质素肽在犬心肌组织和血浆中的表达。
Expression of urocortin peptides in canine myocardium and plasma.
机构信息
Royal (Dick) School of Veterinary Studies, University of Edinburgh Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin EH25 9RG, UK.
出版信息
Vet J. 2011 Jun;188(3):318-24. doi: 10.1016/j.tvjl.2010.05.019. Epub 2010 Jun 15.
Urocortin (Ucn) peptides are the endogenous ligands for the corticotropin-releasing factor type 2 receptor (CRFR2). They have potentially important roles in cardiovascular physiology in health and disease, and show promise as therapeutics for congestive heart failure. Analysis of canine heart tissue showed mRNA expression of Ucn 1, Ucn 3 and CRFR2 in all heart chambers. Immunohistochemistry also demonstrated Ucns 1 and 3 expression in cardiomyocytes. To assess the potential usefulness of circulating Ucns as markers of heart disease, plasma samples from 45 dogs with cardiac disease and 15 controls were analysed by radioimmunoassay. Both Ucns 1 and 3 were measurable but the presence of cardiac disease did not alter their concentrations. Therefore, whilst Ucns are expressed in canine myocardium (where they may play a role in the endogenous neurohumoral response to cardiac disease or failure) they do not appear to be sensitive biomarkers of cardiac disease in our canine patient population.
尿皮质素 (Ucn) 肽是促肾上腺皮质素释放因子 2 型受体 (CRFR2) 的内源性配体。它们在健康和疾病中的心血管生理学中具有潜在的重要作用，并有望成为充血性心力衰竭的治疗药物。对犬心脏组织的分析显示，所有心腔中均有 Ucn1、Ucn3 和 CRFR2 的 mRNA 表达。免疫组织化学还显示 Ucns1 和 3 在心肌细胞中的表达。为了评估循环 Ucns 作为心脏病标志物的潜在用途，用放射免疫分析法分析了 45 只患有心脏病的狗和 15 只对照狗的血浆样本。Ucns1 和 Ucns3 均可测量，但心脏病的存在并未改变它们的浓度。因此，尽管 Ucns 在犬心肌中表达（在那里它们可能在心脏疾病或衰竭的内源性神经激素反应中发挥作用），但它们似乎不是我们犬患者群体中心脏病的敏感生物标志物。
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