Hammett Christopher J K, Prapavessis Harry, Baldi J Chris, Varo Nerea, Schoenbeck Uwe, Ameratunga Rohan, French John K, White Harvey D, Stewart Ralph A H
Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
Am Heart J. 2006 Feb;151(2):367.e7-367.e16. doi: 10.1016/j.ahj.2005.08.009.
Cross-sectional studies suggest that regular exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. We performed a randomized controlled trial to assess whether exercise training decreases levels of 5 inflammatory markers linked to future cardiovascular risk: white blood cell count, fibrinogen, C-reactive protein, soluble intercellular adhesion molecule 1, and soluble CD40 ligand.
One hundred fifty-two healthy female smokers were randomized to either 12 weeks of exercise training or health education as part of a smoking cessation program. Smoking was held steady for the first 6 weeks, and thereafter, smoking cessation was actively attempted. One hundred four participants completed 6 weeks, and 88 completed 12 weeks. Fitness and circulating inflammatory marker levels were measured at baseline, 6 weeks, and 12 weeks. To avoid potential confounding from changes in smoking exposure during the second 6 weeks of the trial, the primary end point was change in inflammatory marker levels from baseline to 6 weeks. Change in inflammatory markers from baseline to 12 weeks was a secondary end point.
At baseline, greater physical fitness was associated with lower white blood cell, fibrinogen, and C-reactive protein levels, but these associations were not statistically significant after adjusting for body mass index (P > .1 for all). Fitness improved significantly in the exercise group at both 6 and 12 weeks. However, there were no differences in levels of any inflammatory marker between the exercise and control groups at either 6 weeks (primary end point) or 12 weeks (secondary end point) (P > .05 for all comparisons).
In female smokers, baseline associations between fitness and inflammatory markers were largely attributable to differences in body fat; regular exercise did not reduce levels of any of the inflammatory markers studied despite a significant improvement in fitness at both 6 and 12 weeks.
横断面研究表明，规律运动具有抗炎作用，可使几种促动脉粥样硬化炎症标志物水平降低。然而，这一点尚未得到随机前瞻性试验的证实。我们进行了一项随机对照试验，以评估运动训练是否能降低与未来心血管风险相关的5种炎症标志物水平：白细胞计数、纤维蛋白原、C反应蛋白、可溶性细胞间黏附分子1和可溶性CD40配体。
152名健康女性吸烟者被随机分为两组，一组进行为期12周的运动训练，另一组接受健康教育，作为戒烟计划的一部分。在最初6周内保持吸烟状态稳定，此后积极尝试戒烟。104名参与者完成了6周的研究，88名完成了12周的研究。在基线、6周和12周时测量体能和循环炎症标志物水平。为避免试验第二个6周期间吸烟暴露变化带来的潜在混杂因素，主要终点是炎症标志物水平从基线到6周的变化。炎症标志物从基线到12周的变化是次要终点。
在基线时，体能较好与白细胞、纤维蛋白原和C反应蛋白水平较低相关，但在调整体重指数后，这些关联无统计学意义（所有P值均>.1）。运动组在6周和12周时体能均显著改善。然而，在6周（主要终点）或12周（次要终点）时，运动组和对照组之间任何炎症标志物水平均无差异（所有比较P值均>.05）。
在女性吸烟者中，体能与炎症标志物之间的基线关联很大程度上归因于体脂差异；尽管在6周和12周时体能有显著改善，但规律运动并未降低所研究的任何炎症标志物水平。
