Wilkins Karl, Turner Ryan, Dolev Jacqueline C, LeBoit Philip E, Berger Timothy G, Maurer Toby A
Department of Dermatology, University of California-San Francisco, California, USA.
J Am Acad Dermatol. 2006 Feb;54(2):189-206; quiz 207-10. doi: 10.1016/j.jaad.2004.11.060.
Certain skin cancers occur with increased frequency or altered course in patients infected with HIV. Malignant melanoma and squamous cell carcinoma are examples of cutaneous malignancies that have a more aggressive course in patients with HIV. Others, such as basal cell carcinoma, appear more frequently in this population but do not appear to be more aggressive. The incidence of HIV-associated Kapsosi's sarcoma has markedly decreased since the advent of HIV antiretroviral therapy. Our understanding of the pathogenesis of this malignancy and its unique management issues are fully reviewed. Cutaneous T-cell lymphoma (CTCL) is rare in this population. Other types of cutaneous lymphoma and HIV-associated pseudo-CTCL are discussed. This article addresses prevention, treatment, and follow-up strategies for this at-risk population.
At the completion of this learning activity, participants should be familiar with the unique epidemiology, clinical course, and management of cutaneous malignancy in patients infected with HIV.
某些皮肤癌在感染HIV的患者中发生频率增加或病程改变。恶性黑色素瘤和鳞状细胞癌是皮肤恶性肿瘤的例子，在HIV患者中病程更具侵袭性。其他的，如基底细胞癌，在这一人群中出现得更频繁，但似乎没有更强的侵袭性。自HIV抗逆转录病毒治疗出现以来，HIV相关卡波西肉瘤的发病率显著下降。本文全面回顾了我们对这种恶性肿瘤发病机制及其独特管理问题的理解。皮肤T细胞淋巴瘤（CTCL）在这一人群中很少见。还讨论了其他类型的皮肤淋巴瘤和HIV相关假性CTCL。本文阐述了针对这一高危人群的预防、治疗和随访策略。
在完成本学习活动后，参与者应熟悉感染HIV患者皮肤恶性肿瘤独特的流行病学、临床病程和管理方法。
