Komorsky-Lovrić Sebojka
Center for Marine and Environmental Research Ruder Bosković Institute, P.O. Box 180 10002, Zagreb, Croatia.
Bioelectrochemistry. 2006 Sep;69(1):82-7. doi: 10.1016/j.bioelechem.2005.10.006. Epub 2006 Jan 27.
Kinetics of the surface redox reactions of adriamycin (doxorubicin hydrochloride) adsorbed on paraffin-impregnated graphite electrode (PIGE) and on mercury electrode is measured by square-wave voltammetry. In 0.9 mol/L KNO3 buffered to pH 4.65, the standard electrode reaction rate constants of the first quinone/hydroquinone redox couple (see Scheme 2) on PIGE and mercury are k(s1)=49+/-12 s(-1) and k(s1)=147+/-36 s(-1), respectively. Under the same conditions, the standard rate constant of the second redox couple on the PIGE is smaller than 4 s(-1) and the electron transfer coefficient of the reduction is alpha2=0.35.
采用方波伏安法测定了吸附在石蜡浸渍石墨电极（PIGE）和汞电极上的阿霉素（盐酸多柔比星）表面氧化还原反应的动力学。在pH值为4.65的0.9 mol/L硝酸钾缓冲溶液中，PIGE和汞电极上第一个醌/对苯二酚氧化还原对（见方案2）的标准电极反应速率常数分别为k(s1)=49±12 s⁻¹和k(s1)=147±36 s⁻¹。在相同条件下，PIGE上第二个氧化还原对的标准速率常数小于4 s⁻¹，还原反应的电子转移系数α2 = 0.35。
