肠道的非免疫防御机制。
Non-immunological defence mechanisms of the gut.
作者信息
Sarker S A, Gyr K
机构信息
Medical Department, Kantonsspital Liestal, University of Basel, Switzerland.
出版信息
Gut. 1992 Jul;33(7):987-93. doi: 10.1136/gut.33.7.987.
Abstract
Non-immunological defence mechanisms represent an important line of intestinal defence in addition to humoral and cellular immunity. This review summarises the evidence for the role of the non-immunological defence system. Protective factors that have been amply documented are gastric juice, intestinal motility, and intestinal flora. Components of pancreatic juice, lysozyme, and epithelial cell turnover may also be involved. Special attention is given to gastric acid, infection with Helicobacter pylori, and hypochlorhydria and their association with infectious diarrhoea. Epidemic hypochlorhydria is discussed since this increases sensitivity to intestinal infections in third world countries.
摘要
非免疫防御机制是除体液免疫和细胞免疫之外肠道防御的重要防线。本综述总结了非免疫防御系统作用的相关证据。已有充分文献记载的保护因子包括胃液、肠道蠕动和肠道菌群。胰液成分、溶菌酶和上皮细胞更新也可能参与其中。特别关注胃酸、幽门螺杆菌感染、胃酸过少及其与感染性腹泻的关联。本文还讨论了流行性胃酸过少，因为它会增加第三世界国家对肠道感染的易感性。
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