Krishnan Sriyesh, Talley Brad D, Slavin Melissa J, Doraiswamy P Murali, Petrella Jeffrey R
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Neuroimaging Clin N Am. 2005 Nov;15(4):853-68, xi. doi: 10.1016/j.nic.2005.09.011.
Advanced MR techniques, such as functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging, offer the capability of detecting early functional, hemodynamic, and microstructural alterations in Alzheimer's disease before gross anatomic alterations. Most studies of these emerging technologies are at the exploratory stage, with the purpose of increasing understanding of the underlying disease process and defining cross-sectional differences across various subject populations. Assessment of the diagnostic efficacy of these technologies in detecting early Alzheimer's disease in its preclinical and prodromal stages is ongoing.
先进的磁共振技术，如功能磁共振成像、灌注加权成像和扩散张量成像，能够在阿尔茨海默病出现明显解剖学改变之前检测到早期的功能、血流动力学和微观结构改变。对这些新兴技术的大多数研究仍处于探索阶段，目的是加深对潜在疾病过程的理解，并确定不同受试者群体之间的横断面差异。目前正在评估这些技术在检测临床前和前驱期早期阿尔茨海默病方面的诊断效能。
