Price Stephen J
Academic Neurosurgery Division, Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, UK.
Br J Neurosurg. 2007 Dec;21(6):562-75. doi: 10.1080/02688690701700935.
Although MRI is the imaging modality of choice for brain tumours, the standard clinical sequences cannot tell us about certain features of brain tumours. Improvements in imaging technology now allow advanced sequences, once used exclusively for research, to be used clinically. Assessment of brain tumours with diffusion weighted MR (a marker of cellularity), diffusion tensor MR (shows integrity of surrounding white matter tracts), perfusion MR (marker of tumour vascularity and angiogenesis), MR spectroscopy (showing tumour metabolism) and functional MR (to identify eloquent cortex) provide information that is complementary to the structural information. These techniques can be used to improve identification of the tumour margin, tumour grading, reducing surgical risk and assessing the response to therapy. It is important for the neurosurgeon to understand what information can be obtained from these sequences, and that they ensure they are used to further develop the assessment and management of brain tumours.
尽管磁共振成像（MRI）是脑肿瘤首选的成像方式，但标准的临床序列无法告知我们脑肿瘤的某些特征。如今成像技术的进步使得曾经仅用于研究的先进序列能够应用于临床。利用扩散加权磁共振成像（一种细胞密度标志物）、扩散张量磁共振成像（显示周围白质束的完整性）、灌注磁共振成像（肿瘤血管生成和血管新生的标志物）、磁共振波谱分析（显示肿瘤代谢）以及功能磁共振成像（识别明确的皮质）对脑肿瘤进行评估，可提供与结构信息互补的信息。这些技术可用于改善肿瘤边缘的识别、肿瘤分级、降低手术风险以及评估治疗反应。神经外科医生了解从这些序列中能获得哪些信息非常重要，并且要确保利用它们进一步完善脑肿瘤的评估和管理。
