Khandekar M M, Khurana A S, Deshmukh S D, Kakrani A L, Katdare A D, Inamdar A K
Department of Pathology, B J Medical College and Sassoon General Hospitals, Pune, 411001, India.
J Clin Pathol. 2006 Feb;59(2):146-9. doi: 10.1136/jcp.2004.025387.
To study platelet volume indices (PVI) in the spectrum of ischaemic heart diseases.
A total of 210 cases were studied; 94 patients had unstable angina (UA) or acute myocardial infarction (AMI) diagnosed on the basis of history, characteristic electrocardiographic changes, and increased cardiac enzyme activities. Seventy patients had stable coronary artery disease (stable CAD) or were admitted for a coronary angiography or coronary artery bypass graft procedure. The third group comprised 30 age and sex matched healthy controls with no history of heart disease and a normal electrocardiogram.
All PVI-mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR)-were significantly raised in patients with AMI and UA (mean MPV, 10.43 (SD, 1.03) fL; mean PDW, 13.19 (SD, 2.34) fL; mean P-LCR, 29.4% (SD, 7.38%)) compared with those with stable CAD (mean MPV, 9.37 (SD, 0.99) fL; mean PDW, 11.35 (SD, 1.95) fL; mean P-LCR, 22.55% (SD, 6.65%)) and the control group (mean MPV, 9.2 (SD, 0.91) fL; mean PDW, 10.75 (SD, l.42) fL; mean P-LCR, 20.65% (SD, 6.14%)).
Larger platelets are haemostatically more active and are a risk factor for developing coronary thrombosis, leading to myocardial infarction. Patients with larger platelets can easily be identified during routine haematological analysis and could possibly benefit from preventive treatment. Thus, PVI are an important, simple, effortless, and cost effective tool that should be used and explored extensively, especially in countries such as India, for predicting the possibility of impending acute events.
研究缺血性心脏病谱中的血小板体积指标（PVI）。
共研究了210例患者；94例患者根据病史、特征性心电图改变及心肌酶活性升高诊断为不稳定型心绞痛（UA）或急性心肌梗死（AMI）。70例患者患有稳定型冠状动脉疾病（稳定型CAD）或因冠状动脉造影或冠状动脉搭桥手术入院。第三组包括30例年龄和性别匹配的健康对照者，无心脏病史且心电图正常。
与稳定型CAD患者（平均血小板体积（MPV）9.37（标准差，0.99）fL；平均血小板分布宽度（PDW）11.35（标准差，1.95）fL；平均血小板大细胞比率（P-LCR）22.55%（标准差，6.65%））及对照组（平均MPV 9.2（标准差，0.91）fL；平均PDW 10.75（标准差，1.42）fL；平均P-LCR 20.65%（标准差，6.14%））相比，AMI和UA患者的所有PVI指标——平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板大细胞比率（P-LCR）——均显著升高（平均MPV 10.43（标准差，1.03）fL；平均PDW 13.19（标准差，2.34）fL；平均P-LCR 29.4%（标准差，7.38%））。
较大的血小板在止血方面更活跃，是发生冠状动脉血栓形成导致心肌梗死的危险因素。血小板较大的患者在常规血液学分析中很容易被识别，可能从预防性治疗中获益。因此，PVI指标都是重要、简单、便捷且具有成本效益的工具，应广泛使用和探索，尤其是在印度等国家，用于预测即将发生急性事件的可能性。
