焦糖色素III对血液淋巴细胞数量的影响：一项关于焦糖色素III免疫毒性的人体研究以及与大鼠研究数据的结果比较。

Effects of Caramel Colour III on the number of blood lymphocytes: a human study on Caramel Colour III immunotoxicity and a comparison of the results with data from rat studies.

作者信息

Houben G F, van Dokkum W, van Loveren H, Penninks A H, Seinen W, Spanhaak S, Ockhuizen T

机构信息

Dept of Immunotoxicology, University of Utrecht, The Netherlands.

出版信息

Food Chem Toxicol. 1992 May;30(5):427-30. doi: 10.1016/0278-6915(92)90070-2.

DOI:10.1016/0278-6915(92)90070-2

PMID:1644384

Abstract

Administration of the colour additive Ammonia Caramel Colour (Caramel Colour III) to rats has been associated with decreased lymphocyte counts, specifically in rats fed a diet low in vitamin B6. This effect is rapidly reversible and is caused by an imidazole derivative (THI) in Caramel Colour III. In the present paper, the conduct of a human study with Caramel Colour III is outlined and the results of blood lymphocyte counts are presented. No decrease in the number of blood lymphocytes occurred in marginally vitamin B6-deficient humans who consumed Caramel Colour III at the acceptable daily intake level (200 mg/kg body weight/day) for 7 days. These data are discussed in relation to the effects of Caramel Colour III and THI on blood lymphocyte numbers in rats.

摘要

给大鼠施用食用色素氨焦糖色（焦糖色III）与淋巴细胞计数减少有关，特别是在喂食低维生素B6饮食的大鼠中。这种效应是迅速可逆的，并且是由焦糖色III中的咪唑衍生物（THI）引起的。在本文中，概述了一项关于焦糖色III的人体研究，并给出了血液淋巴细胞计数的结果。在边缘性维生素B6缺乏的人群中，以可接受的每日摄入量水平（200毫克/千克体重/天）食用焦糖色III 7天，血液淋巴细胞数量没有减少。本文讨论了这些数据与焦糖色III和THI对大鼠血液淋巴细胞数量的影响之间的关系。