Kandelaki E T, Nemsadze K P, Chkhaidze I G, Kherkheulidze M N, Kamkamidze G K
Georgian Med News. 2005 Dec(129):69-73.
Lately the connection of Asthma and RSV drew the sufficient attention. The recurrent wheezing developed during the RSV in children is particularly frequent in the families having history of atopy. The decreased expression of INFgamma may play the role in the pathogenesis of RSV infection. The target of our research was the study of the rate of INFgamma during various clinical courses of RSV-infection and definition of its role in the pathogenesis of ARVI. 52 children with RSV-associated wheezing have been studied, who had first (32) or recurrent episode (20) of bronchial obstruction and whose families had occurrence of atopy. 52 children with non RSV-associated wheezing (III group) and 10 healthy children up to 12 months of age (IV group) were considered as the control groups. Children from all four groups were from families with the history of atopy. INFgamma was measured by enzyme immunoassay (ELISA). Comparison of two groups of wheezing children with RSV infection showed significant reduction of INFgamma level in the group of children with recurrent wheezing vs. the group with first episode of wheezing. INFgamma levels were significantly higher in the two control groups. During the acute respiratory infection induced by RS-virus, which proceeds with the obstruction of respiratory tract (wheezing), reduction of INFgamma was noted and higher frequency of wheezing episodes is associated with more prominent alteration.
最近，哮喘与呼吸道合胞病毒（RSV）的关联引起了足够的关注。在患有特应性病史的家庭中，儿童感染RSV期间出现的反复喘息尤为常见。γ干扰素（INFγ）表达降低可能在RSV感染的发病机制中起作用。我们研究的目的是研究RSV感染不同临床病程中INFγ的水平，并确定其在急性呼吸道感染（ARVI）发病机制中的作用。我们对52名患有RSV相关性喘息的儿童进行了研究，这些儿童首次（32名）或反复出现（20名）支气管阻塞，且其家族有特应性病史。52名非RSV相关性喘息儿童（第三组）和10名12个月以下的健康儿童（第四组）被视为对照组。所有四组儿童均来自有特应性病史的家庭。通过酶联免疫吸附测定（ELISA）测量INFγ。比较两组感染RSV的喘息儿童发现，反复喘息儿童组的INFγ水平明显低于首次喘息儿童组。两个对照组的INFγ水平明显更高。在由RS病毒引起的急性呼吸道感染并伴有呼吸道阻塞（喘息）的过程中，发现INFγ降低，且喘息发作频率越高，改变越明显。
