Chakhunashvili L, Inasaridze A, Svanidze S, Samkharadze J, Chkhaidze I
M. Guramishvili Pediatric Clinic, Tbilisi State Medical University.
Georgian Med News. 2005 Dec(129):78-81.
A total of 43 patients up to 15 years, who underwent appendectomy with preliminary diagnosis of acute appendicitis have been studied at M. Guramishvili Pediatric Clinic in 2004-2005 years. Procalcitonin concentration has been defined in patients' blood sera using the immunoluminometric method (LUMITest PCT, BRAHMS Diagnostika, Berlin, Germany). Analysis of procalcitonin in different groups of patients has shown that increase in procalcitonin correlates with disease severity, and maximally increases in case of peritonitis due to acute destructive appendicitis. The procalcitonin level can be used to confirm the diagnosis of acute appendicitis. It has been suggested that procalcitonin can be used not only as diagnostic marker for acute appendicitis but also as a prognostic marker of it's complications. Using of procalcitonin in case of acute appendicitis would help to carry out timely surgical interventions and predict disease complications.
2004年至2005年期间，在M. 古拉姆什维利儿科诊所对43例15岁以下初步诊断为急性阑尾炎并接受阑尾切除术的患者进行了研究。采用免疫发光法（LUMITest PCT，BRAHMS Diagnostika，德国柏林）测定患者血清中的降钙素原浓度。对不同患者组的降钙素原分析表明，降钙素原升高与疾病严重程度相关，在急性坏疽性阑尾炎引起的腹膜炎时升幅最大。降钙素原水平可用于确诊急性阑尾炎。有人提出，降钙素原不仅可作为急性阑尾炎的诊断标志物，还可作为其并发症的预后标志物。在急性阑尾炎病例中使用降钙素原将有助于及时进行手术干预并预测疾病并发症。
