Iwai Satomi, Endo Kaoru, Hakamata Yoji, Gregory Clare R, Kobayashi Eiji
Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan.
Microsurgery. 2006;26(1):13-6. doi: 10.1002/micr.20203.
Renal transplantation is a potential treatment for irreversible renal failure in pet cats. Our aim is to reduce warm ischemic time by using nonpenetrating vascular closure staples (VCS), thereby improving graft survival. Experimental cats were divided into the VCS group (n = 4; autotransplantation) or suture group (n = 6; allotransplantation). The renal artery was anastomosed with the external iliac artery in an end-to-end fashion, and the renal vein was attached to the external iliac vein in an end-to-side fashion. Warm ischemic time as well as arterial and venous anastomotic times were measured. Cats in the suture group were administrated cyclosporine and prednisolone orally after transplantation. Ischemic and anastomotic times in the VCS group were significantly reduced compared with the suture group. Two of 6 allografts had a ureteral anastomotic stricture, and 4 allografts were rejected. Histological findings of autografts showed normal structure. In conclusion, VCS staples were useful in feline renal transplantation.
肾移植是治疗宠物猫不可逆肾衰竭的一种潜在方法。我们的目标是通过使用非穿透性血管闭合吻合器（VCS）来减少热缺血时间，从而提高移植物存活率。将实验猫分为VCS组（n = 4；自体移植）或缝合组（n = 6；同种异体移植）。肾动脉以端端方式与髂外动脉吻合，肾静脉以端侧方式与髂外静脉相连。测量热缺血时间以及动脉和静脉吻合时间。缝合组的猫在移植后口服环孢素和泼尼松龙。与缝合组相比，VCS组的缺血和吻合时间显著缩短。6个同种异体移植物中有2个出现输尿管吻合口狭窄，4个同种异体移植物被排斥。自体移植物的组织学检查结果显示结构正常。总之，VCS吻合器在猫肾移植中是有用的。
