Haas David M, McCullough William, Olsen Cara H, Shiau Daniel T, Richard John, Fry Emory A, McNamara Michael F
Department of Obstetrics and Gynecology, Naval Medical Center, San Diego, San Diego, California, 34800, USA.
J Reprod Med. 2005 Dec;50(12):915-22.
To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hoursfor anticipated preterm delivery.
A retrospective review of births at <36 weeks' gestation from January 1, 1996, to July 1, January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups.
There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% vs. 83.6%, p=0.03), venous cord blood gas pH (7.31 vs. 7.32, p=0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference.
Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelvehour dosing could be considered an alternative way to deliver antenatal corticosteroids.
确定对于预期早产，每12小时与每24小时给予倍他米松时新生儿结局是否存在差异。
回顾性分析1996年1月1日至2000年7月1日孕周小于36周的分娩情况。查阅产妇和新生儿病历。将分娩分为3组：未接受产前皮质类固醇激素治疗的产妇、每12小时接受一次倍他米松治疗的产妇以及每24小时接受一次倍他米松治疗的产妇。比较各组之间的人口统计学、产科和新生儿变量。
共分析了909例分娩。在两个倍他米松治疗组中，与每24小时给药组相比，每12小时给药组产妇使用抗生素的比例更高（90.4%对83.6%，p=0.03）、脐静脉血气pH值更低（7.31对7.32，p=0.04）以及新生儿使用表面活性剂的比例更高（39.8%对25.5%，p = 0.001）。对于所有其他结局，两组之间没有差异。
在这项回顾性研究中，每12小时给予倍他米松的治疗方案与每24小时给予倍他米松的治疗方案所产生的结局相似。每12小时给药可被视为产前给予皮质类固醇激素的一种替代方式。
