The effect of an oil formulation on the systemic availability of oxfendazole.
作者信息
Ali D N, Chick B F
机构信息
CSIRO Division of Animal Health, McMaster Laboratory, New South Wales, Australia.
出版信息
Int J Parasitol. 1992 Jul;22(4):541-3. doi: 10.1016/0020-7519(92)90158-h.
PMID:1644532
Abstract
Pure oxfendazole (OFZ) suspended in peanut oil and the commercial formulation 'Synanthic' were each intraruminally administered to Merino weaners at 5 mg kg-1. Plasma was collected and concentrations of OFZ, fenbendazole (FBZ) and FBZ sulphone (FBZ.SO2) were determined by HPLC. The maximum concentrations and area under the plasma concentration curve (AUC) of OFZ and FBZ were significantly higher (P less than 0.05) when OFZ was suspended in peanut oil than when administered as the commercial formulation.
摘要
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