Boothe H W, Boothe D M, Komkov A, Hightower D
Department of Veterinary Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
J Am Vet Med Assoc. 1992 Jul 1;201(1):134-41.
Twenty-five animals (21 dogs and 4 cats) in which hepatobiliary scintigraphy (HBS) was performed between 1982 and 1989 were included in a retrospective study to determine the utility of HBS for diagnosis of extrahepatic biliary obstruction. Final diagnoses, which were based on liver biopsy results and surgical findings in all animals, were hepatocellular disease alone (n = 17), hepatocellular disease and extrahepatic biliary obstruction (n = 7), and normal liver (n = 1). Hepatobiliary scintigraphy was performed by use of 99mTc-diisopropyl iminodiacetic acid in all cases. All 7 cases of extrahepatic biliary obstruction were confirmed at surgery. In animals with biliary obstruction, HBS failed to demonstrate radiolabel within either the gallbladder or intestine at any time. Using nonvisualization of the intestine by 180 minutes as the scintigraphic criterion for diagnosis of biliary obstruction, sensitivity was 83% and specificity was 94% in this series. Hepatobiliary scintigraphy was concluded to be an accurate indicator of extrahepatic biliary obstruction in this group of animals. High serum bilirubin concentration at the time HBS was performed did not appear to reduce the diagnostic usefulness of the scintigraphic findings.
1982年至1989年间接受肝胆闪烁显像（HBS）检查的25只动物（21只狗和4只猫）被纳入一项回顾性研究，以确定HBS对肝外胆管梗阻诊断的实用性。所有动物的最终诊断均基于肝活检结果和手术发现，分别为单纯肝细胞疾病（n = 17）、肝细胞疾病合并肝外胆管梗阻（n = 7）和肝脏正常（n = 1）。所有病例均使用99mTc - 二异丙基亚氨基二乙酸进行肝胆闪烁显像。所有7例肝外胆管梗阻病例均在手术中得到证实。在胆管梗阻的动物中，HBS在任何时候均未在胆囊或肠道内显示放射性标记。以180分钟时肠道未显影作为胆管梗阻的闪烁显像诊断标准，该系列研究中敏感性为83%，特异性为94%。得出结论，肝胆闪烁显像在这组动物中是肝外胆管梗阻的准确指标。进行HBS检查时的高血清胆红素浓度似乎并未降低闪烁显像结果的诊断价值。
