Seifert T, Lechner A, Flooh E, Schmidt H, Schmidt R, Fazekas F
Department of Neurology, Medical University Graz, Graz, Austria.
Cerebrovasc Dis. 2006;21(4):266-70. doi: 10.1159/000091225. Epub 2006 Jan 27.
Both the upsilon2 and upsilon4 alleles of the apolipoprotein E gene (APOE) have been reported to be overrepresented in lobar intracerebral hemorrhage and to be associated with cerebral amyloid angiopathy (CAA). These studies were performed primarily on the North American population and investigated in partly selected patient cohorts.
193 consecutive patients suffering from primary intracerebral hemorrhage (ICH) were included in our study. The localization of the ICH, i.e. cortico-subcortical, deep white matter, basal ganglia, brainstem and cerebellum, was put in relation to the APOE genotype and vascular risk factors. In 101 of these patients, the APOE genotype was also correlated to the presence and distribution of microbleeds and other microangiopathy-related damage, as shown by magnetic resonance imaging (MRI).
We found neither an association of a specific APOE genotype with ICH localization nor with microangiopathy-related MRI findings.
In our study of an unselected Central European population, the APOE genotype was not confirmed as a candidate for providing additional diagnostic and potentially prognostic information in patients with ICH.
据报道，载脂蛋白E基因（APOE）的upsilon2和upsilon4等位基因在脑叶脑出血中占比过高，并与脑淀粉样血管病（CAA）相关。这些研究主要在北美人群中进行，且部分是在选定的患者队列中开展。
我们的研究纳入了193例连续的原发性脑出血（ICH）患者。将ICH的定位，即皮质-皮质下、深部白质、基底节、脑干和小脑，与APOE基因型及血管危险因素进行关联分析。在其中101例患者中，APOE基因型还与磁共振成像（MRI）显示的微出血及其他微血管病相关损伤的存在和分布相关。
我们既未发现特定APOE基因型与ICH定位之间存在关联，也未发现其与微血管病相关的MRI表现存在关联。
在我们对未经选择的中欧人群的研究中，未证实APOE基因型可作为为ICH患者提供额外诊断及潜在预后信息的候选因素。
