用纯化的独特抗原来免疫抑制B6RV2白血病的生长。

Inhibition of B6RV2 leukemia growth by immunization with purified unique antigen.

作者信息

Uenaka A, Nakayama E

机构信息

Department of Tumor Immunology, Center for Adult Diseases, Osaka.

出版信息

Jpn J Cancer Res. 1992 Jun;83(6):650-5. doi: 10.1111/j.1349-7006.1992.tb00139.x.

DOI:10.1111/j.1349-7006.1992.tb00139.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918884/

Abstract

Monoclonal antibody (mAb) NU7-99 reacted with only B6RV2 cells, not with 28 other leukemia cell lines, fibroblasts or normal tissues. Biochemical analyses of the unique antigen on B6RV2 cells that reacted with NU7-99 mAb indicated its relationship to xenotropic murine leukemia virus gp70. The antigen that reacted with NU7-99 mAb was extracted from the surface of B6RV2 cells with n-butanol and purified by ion-exchange chromatography and affinity chromatography. Growth of B6RV2 tumors in semi-syngeneic mice was inhibited by immunization of the mice with a purified preparation of this unique antigen.

摘要

单克隆抗体（mAb）NU7-99仅与B6RV2细胞发生反应，而不与其他28种白血病细胞系、成纤维细胞或正常组织发生反应。对与NU7-99 mAb发生反应的B6RV2细胞上的独特抗原进行生化分析，表明其与嗜异性鼠白血病病毒gp70有关。用正丁醇从B6RV2细胞表面提取与NU7-99 mAb发生反应的抗原，并通过离子交换色谱和亲和色谱进行纯化。用这种独特抗原的纯化制剂免疫半同基因小鼠，可抑制B6RV2肿瘤在这些小鼠体内的生长。

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