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丝瓜对蛙腭上皮的影响：组织学特征

Luffa operculata effects on the epithelium of frog palate: histological features.

作者信息

Menon-Miyake Mônica Aidar, Saldiva Paulo Hilário Nascimento, Lorenzi-Filho Geraldo, Ferreira Marcelo Alves, Butugan Ossamu, Oliveira Regiani Carvalho de

机构信息

University of Sao Paulo.

出版信息

Braz J Otorhinolaryngol. 2005 Mar-Apr;71(2):132-8. doi: 10.1016/s1808-8694(15)31300-8. Epub 2005 Aug 2.

DOI:10.1016/s1808-8694(15)31300-8
PMID:16446907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9450526/
Abstract

UNLABELLED

Luffa operculata is the botanical name of buchinha-do-norte or cabacinha, which is a medicinal plant widely used for the treatment of rhinitis and rhinosinusitis. In Europe and USA, it is available in homeopathic medicines. In Brazil, Luffa operculata dry fruit infusion is inhaled or instilled into the nose releasing profuse mucous secretion, thus relieving nasal symptoms. Nevertheless, this often may cause irritation, epistaxis or anosmia.

STUDY DESIGN

Experimental.

MATERIAL AND METHOD

The effects of Luffa operculata were evaluated in different concentration infusions, in isolated frog palate preparation, testing 46 palates after immersion. Four groups (n = 10) were tested with the infusion prepared with frog Ringer (isotonic): control; 60 mg/L; 600 mg/L; and 1200 mg/L. An additional group was tested using the infusion with water (600 mg/L H2O, n = 6). Epithelial samples were harvested to be studied under light microscopy and electron transmission microscopy.

RESULTS

In treated palates, light microscopy findings were dose-dependent standard toxic changes. Electron transmission microscopy showed enlargement of intercellular spaces and tight junctions disruption, pointing to ion-fluid transport abnormalities.

CONCLUSIONS

Luffa operculata infusion in currently used doses can promote significant structural and ultrastructural changes in the epithelium of this ex vivo model of respiratory mucosa.

摘要

未标注

丝瓜（Luffa operculata）是北布钦哈（buchinha-do-norte）或卡巴钦哈（cabacinha）的植物学名，它是一种药用植物，广泛用于治疗鼻炎和鼻窦炎。在欧洲和美国，它可用于顺势疗法药物中。在巴西，吸入或向鼻腔滴注丝瓜干果实浸液可促使大量黏液分泌，从而缓解鼻部症状。然而，这通常可能会引起刺激、鼻出血或嗅觉丧失。

研究设计

实验性研究。

材料与方法

在离体青蛙腭部制备模型中，评估不同浓度丝瓜浸液的作用，浸泡后测试46个腭部。四组（每组n = 10）用青蛙任氏液（等渗）配制的浸液进行测试：对照组；60毫克/升；600毫克/升；以及1200毫克/升。另外一组用蒸馏水浸液（600毫克/升 H₂O，n = 6）进行测试。采集上皮样本，在光学显微镜和透射电子显微镜下进行研究。

结果

在处理过的腭部，光学显微镜检查结果显示出剂量依赖性的标准毒性变化。透射电子显微镜显示细胞间隙增大和紧密连接破坏，表明离子-液体转运异常。

结论

以目前使用的剂量滴注丝瓜浸液可在这种呼吸道黏膜离体模型的上皮中引起显著的结构和超微结构变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/30e401ed12bd/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/657748bf805e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/4cbc638d143b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/3d4b44b84c42/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/1fee75e5a34b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/2570c2582175/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/6369fb525a1c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7228b9738a21/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/113b19f0a028/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7d8072cb51b4/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7321a0139488/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/30e401ed12bd/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/657748bf805e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/4cbc638d143b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/3d4b44b84c42/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/1fee75e5a34b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/2570c2582175/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/6369fb525a1c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7228b9738a21/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/113b19f0a028/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7d8072cb51b4/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/7321a0139488/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/9450526/30e401ed12bd/gr11.jpg

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本文引用的文献

1
Luffa operculata affects mucociliary function of the isolated frog palate.丝瓜（Luffa operculata）影响离体青蛙上颚的黏液纤毛功能。
Am J Rhinol. 2005 Jul-Aug;19(4):353-7.
2
Side-effects of complementary and alternative medicine.补充和替代医学的副作用。
Allergy. 2003 Aug;58(8):707-16. doi: 10.1034/j.1398-9995.2003.00219.x.
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Botanical medicines--the need for new regulations.植物药——新法规的必要性
N Engl J Med. 2002 Dec 19;347(25):2073-6. doi: 10.1056/NEJMsb022858.
4
Tight junction proteins.紧密连接蛋白
Prog Biophys Mol Biol. 2003 Jan;81(1):1-44. doi: 10.1016/s0079-6107(02)00037-8.
5
Potential interactions between herbal medicines and conventional drug therapies used by older adults attending a memory clinic.在记忆门诊就诊的老年人所使用的草药与传统药物疗法之间的潜在相互作用。
Drugs Aging. 2002;19(11):879-86. doi: 10.2165/00002512-200219110-00005.
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Overview of complementary, alternative, and integrative medicine.补充医学、替代医学和整合医学概述。
Clin Obstet Gynecol. 2001 Dec;44(4):774-9. doi: 10.1097/00003081-200112000-00015.
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Efficacy and safety of a fixed-combination homeopathic therapy for sinusitis.一种治疗鼻窦炎的固定复方顺势疗法的疗效与安全性。
Adv Ther. 1999 Mar-Apr;16(2):103-11.
8
A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis.一项比较丝瓜络复方足跟鼻腔喷雾剂与色甘酸钠喷雾剂治疗季节性变应性鼻炎的疗效和安全性的随机等效性试验。
Forsch Komplementarmed. 1999 Jun;6(3):142-8. doi: 10.1159/000021239.
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Patient use of traditional and complementary therapies in treating rhinosinusitis before consulting an otolaryngologist.患者在咨询耳鼻喉科医生之前使用传统和补充疗法治疗鼻窦炎的情况。
Laryngoscope. 1999 Aug;109(8):1223-7. doi: 10.1097/00005537-199908000-00007.
10
The use of the frog palate preparation to assess the effects of oxidants on ciliated epithelium.使用蛙腭制备物来评估氧化剂对纤毛上皮的影响。
Free Radic Biol Med. 1998 Mar 15;24(5):714-21. doi: 10.1016/s0891-5849(97)00332-8.