Olschewski Thomas, Seegenschmiedt Michael Heinrich
Department of Radiotherapy and Radiation Oncology, Alfried Krupp Krankenhaus, Alfried-Krupp-Strasse 21, 45117 Essen, Germany.
Strahlenther Onkol. 2006 Feb;182(2):72-9. doi: 10.1007/s00066-006-1357-7.
To examine the role of radiotherapy (RT) in adult Langerhans cell histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process.
A literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled.
The literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors.
Ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines.
探讨放射治疗（RT）在成人朗格汉斯细胞组织细胞增多症（LCH）骨表现中的作用，明确有关RT的未决问题，并为临床决策和问题解决过程制定建议。
使用不同医学数据库进行了一项涵盖过去三十年的文献综述，并系统整理了有关电离辐射使用的相关问题。
文献综述显示，骨单系统疾病患者的局部控制率为96%（完全缓解率为93%），多系统疾病伴骨受累患者的局部控制率为92%（完全缓解率为76%）。为增加我们的认识，已建立了一个前瞻性登记系统，以便对RT结果进行差异化分析并确定潜在的预后因素。
电离辐射可成功作为单一治疗方法或与其他疗法联合用于LCH的骨表现。它可带来高缓解率和局部控制率。然而，仍存在许多未决问题。建议建立一个前瞻性临床登记系统，以明确RT在该疾病中的确切作用，并制定未来的跨学科治疗指南。
