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脱细胞真皮基质(同种异体脱细胞真皮基质):造口旁疝修补的新材料。

Acellular dermal matrix (AlloDerm): new material in the repair of stoma site hernias.

作者信息

Kish Karen J, Buinewicz Brian R, Morris Jon B

机构信息

Division of General Surgery, Abington Memorial Hospital, Abington, Pennsylvania, USA.

出版信息

Am Surg. 2005 Dec;71(12):1047-50.

Abstract

Parastomal hernias are a common complication after ileostomy or colostomy formation and can lead to complications, such as intestinal obstruction and strangulation. When a parastomal hernia presents, repair of the defect can pose a challenge to the surgeon to choose a repair that both reduces complications and recurrence rates. We present three cases of parastomal hernia repair using acellular dermal matrix (AlloDerm) as reinforcement to the primary hernia repair. We prospectively followed three patients who presented with parastomal hernia after ostomy formation in 2001-2002. The patients underwent repair of the parastomal hernia using primary fascial repair with reinforcement using AlloDerm as an on-lay patch. Two patients were followed for 6 months and 1 year, respectively, and remained hernia-free. One patient presented 8 months later with symptoms of intestinal obstruction that were relieved by nasogastric tube decompression and bowel rest. The patient subsequently returned 3 months later with intestinal obstruction and recurrent parastomal hernia that necessitated an operation for relocation of the stoma and repeat hernia repair. Repair of parastomal hernias using AlloDerm acellular dermal matrix as a substitute for a synthetic graft showed resilience to infection and, more importantly, tolerated exposure in an open wound without having to be removed. Larger studies with longer follow-up are needed to see if this material reduces the incidence of hernia recurrence.

摘要

造口旁疝是回肠造口术或结肠造口术形成后的常见并发症,可导致肠梗阻和绞窄等并发症。当出现造口旁疝时,修复缺损对外科医生来说是一项挑战,需要选择一种既能降低并发症又能降低复发率的修复方法。我们报告三例使用脱细胞真皮基质(AlloDerm)作为原发性疝修补术的加固材料进行造口旁疝修补的病例。我们前瞻性地随访了2001年至2002年造口形成后出现造口旁疝的三名患者。这些患者接受了造口旁疝修补术,采用原发性筋膜修补术,并使用AlloDerm作为覆盖补片进行加固。两名患者分别随访了6个月和1年,均无疝复发。一名患者在8个月后出现肠梗阻症状,经鼻胃管减压和肠道休息后症状缓解。该患者随后在3个月后因肠梗阻和复发性造口旁疝再次就诊,需要进行造口重新定位手术和再次疝修补术。使用AlloDerm脱细胞真皮基质替代合成移植物进行造口旁疝修补显示出对感染的抵抗力,更重要的是,它能耐受在开放伤口中的暴露,无需取出。需要进行更大规模、更长时间随访的研究,以确定这种材料是否能降低疝复发的发生率。

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