乙酰胆碱诱导胸腺淋巴母细胞DNA合成及增殖的起始过程。
Acetylcholine-induced initiation of thymic lymphoblast DNA synthesis and proliferation.
作者信息
MacManus J P, Boynton A L, Whitfield J F, Gillan D J, Isaacs R J
出版信息
J Cell Physiol. 1975 Apr;85(2 Pt 1):321-9. doi: 10.1002/jcp.1040850218.
Low (5 times 10-9 M to 10-7 M) acetylcholine concentrations cause a calcium-independent stimulation of the initiation of DNA synthesis and proliferation of lymphoblasts which are part of rat thymocyte populations suspended in vitro. A much higher (5 times 10-5 M) acetylcholine concentration also stimulates lymphoblast DNA synthesis and proliferation, but this action is calcium-dependent. This proliferogenic response to acetylcholine is however not clearly mediated by either cyclic GMP or cyclic AMP.
低浓度（5×10⁻⁹ M至10⁻⁷ M）的乙酰胆碱可引起对DNA合成起始的钙非依赖性刺激以及体外悬浮的大鼠胸腺细胞群体中淋巴母细胞的增殖。高得多的（5×10⁻⁵ M）乙酰胆碱浓度也刺激淋巴母细胞DNA合成和增殖，但此作用是钙依赖性的。然而，这种对乙酰胆碱的促增殖反应并非由环鸟苷酸或环腺苷酸明确介导。
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