Inase Naohiko, Tominaga Shinichirou, Yasui Makito, Tsukada Yoshikazu, Oukouchi Minoru, Miura Hirotarou
Department of Internal Medicine, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka-shi, Kanagawa 238-8558, Japan.
Kekkaku. 2005 Dec;80(12):731-4.
We examined the usefulness of adenosine deaminase 2 (ADA2) in the diagnosis of tuberculous pleuritis.
A hundred cases, 78 male and 22 female, with pleural effusion were examined. With regard to pleural effusion, 18 cases were transudate and 82 cases (9 tuberculous pleuritis, 27 lung cancer, 8 mesothelioma, 5 malignant diseases except lung cancer and mesothelioma, 5 benign asbestos pleurisy, 10 empyema, 10 parapneumonic effusion, one SLE, one parasitic infection, and 6 undetermined etiology) were exudates. The last 6 cases with unknown origin were excluded in this study.
Pleural adenosine deaminase (ADA) was 90.4 +/- 22.4 U/l (mean +/- SD) and pleural ADA2 was 80.4 +/- 21.9 U/l in tuberculous pleuritis, both were significantly higher than those in non-tuberculous exudates (p < 0.001). In the diagnosis of tuberculous pleuritis, pleural ADA showed 100% sensitivity and 88% specificity, whereas pleural ADA2 showed 100% sensitivity and 91% specificity.
Pleural ADA2 is useful in the diagnosis of tuberculous pleuritis, which has similar sensitivity and a little better specificity compared with pleural ADA.
我们研究了腺苷脱氨酶2（ADA2）在结核性胸膜炎诊断中的实用性。
对100例胸腔积液患者进行了检查，其中男性78例，女性22例。关于胸腔积液，18例为漏出液，82例（9例结核性胸膜炎、27例肺癌、8例间皮瘤、5例非肺癌和间皮瘤的恶性疾病、5例良性石棉胸膜炎、10例脓胸、10例肺炎旁胸腔积液、1例系统性红斑狼疮、1例寄生虫感染以及6例病因不明）为渗出液。本研究排除了最后6例病因不明的病例。
结核性胸膜炎患者的胸腔腺苷脱氨酶（ADA）为90.4±22.4 U/l（均值±标准差），胸腔ADA2为80.4±21.9 U/l，两者均显著高于非结核性渗出液（p<0.001）。在结核性胸膜炎的诊断中，胸腔ADA的敏感性为100%，特异性为88%，而胸腔ADA2的敏感性为100%，特异性为91%。
胸腔ADA2在结核性胸膜炎的诊断中具有实用性，与胸腔ADA相比，其敏感性相似，特异性稍好。
Zotero 插件