de Tessieres C, Saffar J L
Laboratoire de Biologie et Biomatériaux, Université Paris-V. Faculté de Chirurgie Dentaire, Montrouge, France.
J Biol Buccale. 1992 Jun;20(2):117-20.
Femoral osteopenic changes characterized by a fall in metaphyseal trabecular bone volume (TBV) have been previously reported in hamsters fed a high carbohydrate diet for 45 days. In the present study the effects of the diet were assessed after 90 days. Serum P was significantly reduced (p less than 0.05) in experimental animals; serum Ca was unaltered. Disturbances in body growth had occurred as shown by a reduction in body weight gain (p less than 0.05) in the first 45 days of the experiment and by a decrease in femoral size (p less than 0.02). Osteopenia had also developed: the epiphyseal TBV decreased (p less than 0.05) as well as the thickness of both epiphyseal and metaphyseal trabeculae (p less than 0.001). However signs of partial recovery from this condition were observed as shown by an increased body weight gain in the last 45 days of the experiment (p less than 0.02) and lack of difference in metaphyseal TBV, assumed to be the more labile, between the 2 groups. Moreover bone formation significantly increased along metaphyseal trabeculae and the endosteal aspect of the cortices.
先前有报道称，给仓鼠喂食高碳水化合物饮食45天后，其股骨出现骨质减少性变化，特征为干骺端小梁骨体积（TBV）下降。在本研究中，评估了90天后该饮食的影响。实验动物的血清磷显著降低（p<0.05）；血清钙未改变。实验前45天体重增加减少（p<0.05）以及股骨尺寸减小（p<0.02）表明身体生长出现紊乱。骨质减少也已出现：骨骺TBV降低（p<0.05），骨骺和干骺端小梁厚度均减小（p<0.001）。然而，观察到这种状况有部分恢复的迹象，如实验最后45天体重增加增多（p<0.02），且两组之间干骺端TBV（假定其更不稳定）无差异。此外，沿干骺端小梁和皮质骨内膜面的骨形成显著增加。
