Noda-Tsuruya Tomoko, Asano-Kato Naoko, Toda Ikuko, Tsubota Kazuo
Minamiaoyama Eye Clinic, Tokyo, Japan.
J Refract Surg. 2006 Jan-Feb;22(1):61-6. doi: 10.3928/1081-597X-20060101-13.
To evaluate the efficacy of autologous serum eye drops for dry eye after LASIK in a prospective, randomized study.
Fifty-four eyes of 27 male patients who underwent LASIK were divided into two groups; patients who used autologous serum eye drops and those who used artificial tears postoperatively. Schirmer test with anesthesia, tear break-up time (BUT), and rose bengal and fluorescein staining for the ocular surface were prospectively compared between the groups. All values were also compared before and after surgery (at 1 week [except for Schirmer test], 1 month, 3 months, and 6 months) in each group.
Tear BUT was greater in the autologous serum eye drops group than in the artificial tears group at 6 months postoperatively. Rose bengal score was lower in patients using autologous serum eye drops than in patients using artificial tears at 1 month and 3 months postoperatively. No significant difference was noted between patients using autologous serum eye drops and patients using artificial tears in the value of Schirmer test with anesthesia and fluorescein scores. In the autologous serum eye drops group, tear BUT was increased at 3 months after LASIK, rose bengal score was lower at 1 month and 3 months, and fluorescein score was lower at 1 month after LASIK compared to preoperative values, respectively. In the artificial tears group, all values (Schirmer test, tear BUT, rose bengal score, and fluorescein score) showed no differences between before and after LASIK. No differences were noted in the subjective scores for dryness between the autologous serum eye drops and artificial tears groups.
The autologous serum eye drops group showed prolongation of the tear BUT and a reduction in rose bengal staining score.
在一项前瞻性随机研究中评估自体血清滴眼液对LASIK术后干眼症的疗效。
27例接受LASIK手术的男性患者的54只眼被分为两组；一组术后使用自体血清滴眼液，另一组术后使用人工泪液。前瞻性比较两组之间的表面麻醉下泪液分泌试验、泪膜破裂时间（BUT）以及眼表的孟加拉玫瑰红和荧光素染色情况。每组还比较了手术前后（术后1周[泪液分泌试验除外]、1个月、3个月和6个月）的所有数值。
术后6个月时，自体血清滴眼液组的泪膜破裂时间比人工泪液组更长。术后1个月和3个月时，使用自体血清滴眼液的患者孟加拉玫瑰红评分低于使用人工泪液的患者。在表面麻醉下泪液分泌试验值和荧光素评分方面，使用自体血清滴眼液的患者与使用人工泪液的患者之间未观察到显著差异。在自体血清滴眼液组中，与术前值相比，LASIK术后3个月时泪膜破裂时间增加，术后1个月和3个月时孟加拉玫瑰红评分降低，术后1个月时荧光素评分降低。在人工泪液组中，所有数值（泪液分泌试验、泪膜破裂时间、孟加拉玫瑰红评分和荧光素评分）在LASIK前后均无差异。自体血清滴眼液组和人工泪液组在干眼主观评分方面无差异。
自体血清滴眼液组显示泪膜破裂时间延长，孟加拉玫瑰红染色评分降低。
