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1
The dehydratase activity of lacticin 481 synthetase is highly processive.
J Am Chem Soc. 2006 Feb 8;128(5):1420-1. doi: 10.1021/ja057203d.
2
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production.
J Am Chem Soc. 2005 Nov 9;127(44):15332-3. doi: 10.1021/ja0543043.
3
Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.
Chem Biol. 2006 Oct;13(10):1109-17. doi: 10.1016/j.chembiol.2006.08.015.
4
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
Biochemistry. 2008 Jul 15;47(28):7342-51. doi: 10.1021/bi800277d. Epub 2008 Jun 21.
5
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity.
Biochemistry. 2007 May 29;46(21):6268-76. doi: 10.1021/bi7000104. Epub 2007 May 5.
6
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.
Science. 2004 Jan 30;303(5658):679-81. doi: 10.1126/science.1092600.
7
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.
Biochemistry. 2007 May 22;46(20):5991-6000. doi: 10.1021/bi602663x. Epub 2007 Apr 25.
9
Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.
J Am Chem Soc. 2016 May 25;138(20):6436-44. doi: 10.1021/jacs.6b00163. Epub 2016 May 10.
10
Characterization of modification enzyme NukM and engineering of a novel thioether bridge in lantibiotic nukacin ISK-1.
Appl Microbiol Biotechnol. 2010 Apr;86(3):891-9. doi: 10.1007/s00253-009-2334-8. Epub 2009 Nov 14.

引用本文的文献

1
Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome.
Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219392120. doi: 10.1073/pnas.2219392120. Epub 2023 May 22.
3
Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.
J Am Chem Soc. 2017 Dec 27;139(51):18623-18631. doi: 10.1021/jacs.7b10203. Epub 2017 Dec 15.
4
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.
Chem Rev. 2017 Apr 26;117(8):5619-5674. doi: 10.1021/acs.chemrev.6b00571. Epub 2017 Jan 20.
5
Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence.
Antimicrob Agents Chemother. 2010 Apr;54(4):1498-505. doi: 10.1128/AAC.00883-09. Epub 2010 Jan 25.
6
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.
Nat Prod Rep. 2009 Apr;26(4):537-59. doi: 10.1039/b714132g.
7
Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin.
Appl Environ Microbiol. 2008 Nov;74(21):6591-7. doi: 10.1128/AEM.01334-08. Epub 2008 Sep 12.
8
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
Biochemistry. 2008 Jul 15;47(28):7342-51. doi: 10.1021/bi800277d. Epub 2008 Jun 21.
9
The leader peptide is not required for post-translational modification by lacticin 481 synthetase.
J Am Chem Soc. 2007 Aug 29;129(34):10314-5. doi: 10.1021/ja072967+. Epub 2007 Aug 4.
10
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity.
Biochemistry. 2007 May 29;46(21):6268-76. doi: 10.1021/bi7000104. Epub 2007 May 5.

本文引用的文献

1
Biosynthesis and mode of action of lantibiotics.
Chem Rev. 2005 Feb;105(2):633-84. doi: 10.1021/cr030105v.
2
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.
Science. 2004 Jan 30;303(5658):679-81. doi: 10.1126/science.1092600.
3
Processive phosphorylation of alternative splicing factor/splicing factor 2.
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12601-6. doi: 10.1073/pnas.1635129100. Epub 2003 Oct 10.
4
A structural basis for processivity.
Protein Sci. 2001 Sep;10(9):1699-711. doi: 10.1110/ps.10301.
5
A peptide model system for processive phosphorylation by Src family kinases.
Biochemistry. 2000 Nov 28;39(47):14531-7. doi: 10.1021/bi001850u.
7
The fidelity of DNA polymerase beta during distributive and processive DNA synthesis.
J Biol Chem. 1999 Feb 5;274(6):3642-50. doi: 10.1074/jbc.274.6.3642.
8
A novel methodology for assignment of disulfide bond pairings in proteins.
Protein Sci. 1997 Feb;6(2):391-8. doi: 10.1002/pro.5560060215.
9
The isotope trapping method: desorption rates of productive E.S complexes.
Methods Enzymol. 1980;64:47-59. doi: 10.1016/s0076-6879(80)64004-x.

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