单相硅取代α-磷酸三钙的合成与表征

Synthesis and characterization of single-phase silicon-substituted alpha-tricalcium phosphate.

作者信息

Reid Joel W, Tuck Loughlin, Sayer Michael, Fargo Karen, Hendry Jason A

机构信息

Millenium Biologix Corp., 785 Midpark Drive, Kingston, Ont., Canada K7M 7G3.

出版信息

Biomaterials. 2006 May;27(15):2916-25. doi: 10.1016/j.biomaterials.2006.01.007. Epub 2006 Jan 30.

DOI:10.1016/j.biomaterials.2006.01.007

PMID:16448694

Abstract

Silicon-substituted calcium phosphate (CaP) powders with a Ca/(P+Si) ratio of 1.50 have been prepared by a wet chemical method, with silicon contents up to 2.16 weight percent (wt%). Sintering for 2 h at 1250 degrees C yields single-phase silicon-substituted alpha tricalcium phosphate (Si-alpha-TCP) for compositions between 0.59 and 1.14 wt% silicon. The sintered powders have been characterized with X-ray fluorescence (XRF) spectrometry, X-ray diffraction (XRD), attenuated total reflection infrared spectroscopy (ATR-IR) and transmission electron microscopy (TEM). Compositions with less than 0.59 wt% silicon result in mixtures of Si-alpha-TCP, beta-TCP, and calcium hydroxyapatite (HA), while compositions with more than 1.14 wt% silicon result in mixtures of Si-alpha-TCP and HA. The lattice parameters of single-phase Si-alpha-TCP prepared with 0.87 wt% silicon are a=12.874(1)A, b = 27.372(2) A, c = 15.225(1) A, and beta = 126.38(1) degrees .

摘要

通过湿化学法制备了钙磷比（Ca/(P+Si)）为1.50的硅取代磷酸钙（CaP）粉末，硅含量高达2.16重量百分比（wt%）。在1250℃下烧结2小时，对于硅含量在0.59至1.14 wt%之间的成分，可得到单相硅取代α-磷酸三钙（Si-α-TCP）。已通过X射线荧光（XRF）光谱法、X射线衍射（XRD）、衰减全反射红外光谱法（ATR-IR）和透射电子显微镜（TEM）对烧结粉末进行了表征。硅含量低于0.59 wt%的成分会导致Si-α-TCP、β-磷酸三钙（β-TCP）和羟基磷灰石（HA）的混合物，而硅含量高于1.14 wt%的成分会导致Si-α-TCP和HA的混合物。用0.87 wt%的硅制备的单相Si-α-TCP的晶格参数为a = 12.874(1)Å，b = 27.372(2) Å，c = 15.225(1) Å，β = 126.38(1)° 。