Bishop Mark, Brunt Denis, Marjama-Lyons Jill
Department of Physical Therapy, Box 100154, University of Florida, Gainesville, FL 32610-0154, USA.
Neurosci Lett. 2006 Apr 24;397(3):240-4. doi: 10.1016/j.neulet.2005.12.031. Epub 2006 Jan 31.
In light of the movement control problems reported for patients with Parkinson's disease (PD), we examined the lower extremity control strategies used by these subjects to stop walking in planned and unplanned situations. We compared how patients with PD and age and gender-matched control subjects modulated lower extremity muscular activity and ground reaction forces during planned and unplanned stoppings. The main findings were that control subjects did not alter muscle activation from planned to unplanned stopping, relative to stance limb kinetic events; they just increased the amplitude of the response (by approximately 800%). We speculate that these data provide preliminary evidence in support of a stereotypical sequence of muscle activation for gait termination whether planned or unplanned. In contrast, subjects with PD appeared to adopt a different strategy when stopping unexpectedly compared to planned stopping. Additional data show that subjects with PD required additional steps to stop walking when stopping unexpectedly as compared to control subjects.
鉴于帕金森病（PD）患者所报告的运动控制问题，我们研究了这些受试者在有计划和无计划情况下停止行走时所采用的下肢控制策略。我们比较了帕金森病患者以及年龄和性别匹配的对照受试者在有计划和无计划停止过程中如何调节下肢肌肉活动和地面反作用力。主要发现是，相对于支撑肢体动力学事件，对照受试者从有计划到无计划停止时并未改变肌肉激活情况；他们只是增加了反应的幅度（约增加800%）。我们推测，这些数据为步态终止时肌肉激活的刻板序列提供了初步证据，无论这种终止是有计划的还是无计划的。相比之下，帕金森病患者在意外停止时似乎采用了与有计划停止时不同的策略。额外数据表明，与对照受试者相比，帕金森病患者在意外停止时需要额外的步骤来停止行走。
