Clinical Research Centre for Movement Disorders and Gait, Kingston Centre, Warrigal Road, Cheltenham, Victoria 3192, Australia.
Parkinsonism Relat Disord. 2010 Mar;16(3):191-6. doi: 10.1016/j.parkreldis.2009.11.008. Epub 2009 Dec 11.
The aim of this study was to quantify gait termination in people with Parkinson (PwP) as the basis for understanding the underlying pathophysiology of stopping difficulties. Fourteen PwP and 14 age- and gender-matched comparisons completed five trials each of four walking tasks: preferred walk, preferred walk with secondary motor task, coming to a planned stop, and planned stop with a secondary motor task. Spatio-temporal data of walks were compared to steady state walking in stopping trials. Results showed that PwP walked with shorter step length, slower speed, yet similar cadence to comparisons. Both groups decreased step length and step speed when performing a secondary task. Neither group showed changes of gait characteristics in steady state walking prior to stopping. For stopping trials, the number of steps, time, and distance taken to stop were compared for PwP and controls. In planned stops PwP used more steps and took a longer time to stop, but both groups stopped within a similar distance. A secondary motor task did not alter stopping distance or number of steps to stop, but stopping time increased in the comparisons. The results indicate that central control mechanisms regulating planned stopping appear to be intact in people with mild to moderate Parkinson.
本研究旨在量化帕金森病（PD）患者的步态终止，以此作为理解停止困难的潜在病理生理学基础。14 名 PD 患者和 14 名年龄和性别匹配的对照组完成了每个 4 个步行任务的 5 次试验：首选步行、首选步行加次要运动任务、计划停止和计划停止加次要运动任务。与停止试验中的稳态行走相比，对行走的时空数据进行了比较。结果表明，PD 患者的步长更短、速度更慢，但与对照组相比，步频相似。两组在执行次要任务时都减少了步长和步速。两组在停止前的稳态行走中均未表现出步态特征的变化。对于停止试验，比较 PD 患者和对照组停止所需的步数、时间和距离。在计划停止中，PD 患者使用更多的步数并花费更长的时间停止，但两组停止的距离相似。次要运动任务不会改变停止距离或停止所需的步数，但在对照组中停止时间增加。结果表明，在轻度至中度帕金森病患者中，调节计划停止的中枢控制机制似乎完好无损。
