斑马鱼发育过程中类视黄醇X受体基因rxra、rxrba、rxrbb和rxrg的特征分析
Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development.
作者信息
Tallafuss Alexandra, Hale Laura A, Yan Yi-Lin, Dudley Leana, Eisen Judith S, Postlethwait John H
机构信息
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA.
出版信息
Gene Expr Patterns. 2006 Jun;6(5):556-65. doi: 10.1016/j.modgep.2005.10.005. Epub 2006 Jan 30.
During development of vertebrate embryos, retinoic acid plays a variety of roles that are mediated by binding to retinoic acid receptors (Rars) and their heterodimerization partners, the retinoid receptors (Rxrs). Here, we characterize the expression patterns of four zebrafish rxr genes during development and provide an analysis of the phylogenetic relationships between zebrafish and tetrapod Rxr genes based on sequence similarities and conserved syntenies. This analysis prompted the renaming of several of the zebrafish rxr genes to match their tetrapod orthologs. Understanding phylogenetic relationships among Rxr genes and their expression patterns during development provides a foundation for future studies of Rxr functions.
在脊椎动物胚胎发育过程中，视黄酸发挥着多种作用，这些作用是通过与视黄酸受体（Rars）及其异源二聚体伙伴类视黄醇受体（Rxrs）结合来介导的。在这里，我们描述了四个斑马鱼rxr基因在发育过程中的表达模式，并基于序列相似性和保守的共线性关系，对斑马鱼和四足动物Rxr基因之间的系统发育关系进行了分析。这项分析促使我们对几个斑马鱼rxr基因进行重新命名，以匹配它们的四足动物直系同源基因。了解Rxr基因之间的系统发育关系及其在发育过程中的表达模式，为未来研究Rxr功能奠定了基础。
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