Hawkins Matthew R, Wingert Rebecca A
Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USA.
Biomedicines. 2023 Apr 15;11(4):1180. doi: 10.3390/biomedicines11041180.
Retinoic acid (RA) is a metabolite of vitamin A (retinol) that plays various roles in development to influence differentiation, patterning, and organogenesis. RA also serves as a crucial homeostatic regulator in adult tissues. The role of RA and its associated pathways are well conserved from zebrafish to humans in both development and disease. This makes the zebrafish a natural model for further interrogation into the functions of RA and RA-associated maladies for the sake of basic research, as well as human health. In this review, we explore both foundational and recent studies using zebrafish as a translational model for investigating RA from the molecular to the organismal scale.
视黄酸（RA）是维生素A（视黄醇）的一种代谢产物，在发育过程中发挥多种作用，影响细胞分化、模式形成和器官发生。RA在成体组织中也是一种关键的稳态调节因子。从斑马鱼到人类，RA及其相关信号通路在发育和疾病中的作用都高度保守。这使得斑马鱼成为一个天然模型，可用于基础研究以及人类健康领域，进一步探究RA的功能和与RA相关的疾病。在这篇综述中，我们探讨了以斑马鱼为转化模型，从分子水平到机体水平研究RA的基础研究和最新研究。
