控制良好的哮喘患者支气管扩张剂反应性的决定因素

Determinants of bronchodilator responsiveness in patients with controlled asthma.

作者信息

Koga Takeharu, Kamimura Tomoko, Oshita Yuichi, Narita Yuko, Mukaino Tatsuya, Nishimura Munetsugu, Mizoguchi Yusuke, Aizawa Hisamichi

机构信息

First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

出版信息

J Asthma. 2006 Jan-Feb;43(1):71-4. doi: 10.1080/02770900500448662.

DOI:10.1080/02770900500448662

PMID:16448969

Abstract

Short-term bronchodilator responsiveness to an inhaled ss 2 adrenergic agonist was assessed by changes in forced expiratory volume in 1 second (FEV(1)) in nonsmoking adults with controlled asthma (mild disease, 20 patients; moderate disease, 20 patients; severe disease, 18 patients). Responsiveness correlated significantly with age and with percent of predicted FEV(1) (%FEV(1)) except in patients with severe asthma, who showed significantly less responsiveness than others. Thus, responsiveness is closely associated with degree of airflow limitation in patients with controlled asthma and is significantly influenced by severity of disease and by aging.

摘要

通过测量一秒用力呼气容积（FEV(1)）的变化，评估了非吸烟成年哮喘控制患者（轻度疾病20例、中度疾病20例、重度疾病18例）对吸入性β2肾上腺素能激动剂的短期支气管扩张反应性。除重度哮喘患者外，反应性与年龄和预计FEV(1)百分比（%FEV(1)）显著相关，重度哮喘患者的反应性明显低于其他患者。因此，反应性与哮喘控制患者的气流受限程度密切相关，并受疾病严重程度和年龄的显著影响。