Koga Takeharu, Kamimura Tomoko, Oshita Yuichi, Narita Yuko, Mukaino Tatsuya, Nishimura Munetsugu, Mizoguchi Yusuke, Aizawa Hisamichi
First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
J Asthma. 2006 Jan-Feb;43(1):71-4. doi: 10.1080/02770900500448662.
Short-term bronchodilator responsiveness to an inhaled ss 2 adrenergic agonist was assessed by changes in forced expiratory volume in 1 second (FEV(1)) in nonsmoking adults with controlled asthma (mild disease, 20 patients; moderate disease, 20 patients; severe disease, 18 patients). Responsiveness correlated significantly with age and with percent of predicted FEV(1) (%FEV(1)) except in patients with severe asthma, who showed significantly less responsiveness than others. Thus, responsiveness is closely associated with degree of airflow limitation in patients with controlled asthma and is significantly influenced by severity of disease and by aging.
通过测量一秒用力呼气容积（FEV(1)）的变化，评估了非吸烟成年哮喘控制患者（轻度疾病20例、中度疾病20例、重度疾病18例）对吸入性β2肾上腺素能激动剂的短期支气管扩张反应性。除重度哮喘患者外，反应性与年龄和预计FEV(1)百分比（%FEV(1)）显著相关，重度哮喘患者的反应性明显低于其他患者。因此，反应性与哮喘控制患者的气流受限程度密切相关，并受疾病严重程度和年龄的显著影响。
