Feiz-Erfan I, Zabramski J M, Herrmann L L, Coons S W
Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA.
Acta Neurochir (Wien). 2006 Jun;148(6):647-52; discussion 652. doi: 10.1007/s00701-005-0716-y. Epub 2006 Jan 30.
The finding of cavernous malformations within tumors of the central or peripheral nervous system is a rare occurrence. We report a case of a histologically proven cavernous malformation found within an eighth cranial nerve schwannoma in a 76-year-old man. The patient presented with progressive loss of hearing on the left, facial pain and dysesthesia. Symptoms improved significantly after the tumor was subtotally resected through a left retrosigmoid craniotomy. Including the present report, 34 cases of cavernous malformations associated with tumors of nervous system origin, 24 cases (71%) involving tumors of Schwann cell origin, and 9 cases (26%) involving gliomas have been published. The cases were classified into two forms based on the type of association. Conjoined association, in which the cavernous malformation is located within the tissue of the nervous system tumor, and discrete association, in which the cavernous malformation and nervous system tumor are in separate locations. We explore the etiology of this association and hypothesize that a common genetic pathway may be involved in a majority of these cases.
在中枢或周围神经系统肿瘤中发现海绵状血管畸形是一种罕见的情况。我们报告一例组织学证实的海绵状血管畸形,该病例发生在一名76岁男性的第八颅神经鞘瘤内。患者表现为左侧听力进行性丧失、面部疼痛和感觉异常。通过左侧乙状窦后开颅术对肿瘤进行次全切除后,症状明显改善。包括本报告在内,已发表了34例与神经系统起源肿瘤相关的海绵状血管畸形病例,其中24例(71%)涉及施万细胞起源的肿瘤,9例(26%)涉及胶质瘤。根据关联类型,这些病例分为两种形式。联合关联,即海绵状血管畸形位于神经系统肿瘤组织内;离散关联,即海绵状血管畸形和神经系统肿瘤位于不同位置。我们探讨了这种关联的病因,并假设大多数此类病例可能涉及共同的遗传途径。