Solomon H, Samarasinghe Y P, Feher M D, Man J, Rivas-Toro H, Lumb P J, Wierzbicki A S, Jackson G
Department of Cardiology, Cardiothoracic Centre, St. Thomas' Hospital, Lambeth Palace Road, London, UK.
Int J Clin Pract. 2006 Feb;60(2):141-5. doi: 10.1111/j.1742-1241.2006.00793.x.
Erectile dysfunction (ED) has been associated with risk factors for atherosclerosis. Medications used for atherosclerosis have also been implicated in ED. The aim of this study is to investigate the relationship of erectile function to cardiovascular risk factors and specific drug therapies before and after 6 months of statin therapy. In this prospective observational study, International Index of Erectile Function (IIEF) scores were measured in 93 men attending cardiovascular risk clinics. Cardiovascular risk factors and drug therapies were assessed prior to initiation and after 6 months of statin therapy. Prior to statin therapy, the median IIEF score was 21 (range 0-25), and 57% had impairment of erectile function. After statin therapy, IIEF scores were reduced to 6.5 (range 0-25) (p < 0.001), and 22% experienced new onset ED. Before statin therapy no correlation was observed between IIEF score and any individual cardiovascular risk factor. After 6 months of statin therapy, correlations were observed between lower IIEF scores (r = 0.62; p < 0.001) and age and diabetes and weakly with smoking. Differences in dose, relative efficacy or relative lipophilicity of statin prescribed showed no correlation with change in IIEF score. This study suggests ED following statin therapy is more likely in patients with severe endothelial dysfunction due to established cardiovascular risk factors including age, smoking and diabetes.
勃起功能障碍（ED）与动脉粥样硬化的危险因素相关。用于治疗动脉粥样硬化的药物也与ED有关。本研究的目的是调查在他汀类药物治疗6个月前后勃起功能与心血管危险因素及特定药物治疗之间的关系。在这项前瞻性观察研究中，对93名前往心血管风险诊所就诊的男性进行了国际勃起功能指数（IIEF）评分测量。在开始他汀类药物治疗前及治疗6个月后评估心血管危险因素和药物治疗情况。在他汀类药物治疗前，IIEF评分中位数为21（范围0 - 25），57%的患者存在勃起功能障碍。他汀类药物治疗后，IIEF评分降至6.5（范围0 - 25）（p < 0.001），22%的患者出现新发ED。在他汀类药物治疗前，未观察到IIEF评分与任何个体心血管危险因素之间存在相关性。他汀类药物治疗6个月后，观察到较低的IIEF评分（r = 0.62；p < 0.001）与年龄、糖尿病相关，与吸烟的相关性较弱。所开具他汀类药物的剂量、相对疗效或相对亲脂性差异与IIEF评分变化无相关性。本研究表明，由于存在包括年龄、吸烟和糖尿病在内的既定心血管危险因素，导致严重内皮功能障碍的患者在他汀类药物治疗后更易出现ED。
