Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S157. doi: 10.1186/1471-2156-6-S1-S157.
We report a simple and rapid method for detecting additive genetic variance due to X-linked loci in the absence of marker data for this chromosome. We examined the interaction of this method with an established method for detecting mitochondrial linkage (another source of sex-asymmetric genetic covariance). When applied to data from the Collaborative Study on the Genetics of Alcoholism, this method found evidence of X-chromosomal linkage for one continuous trait (ntth1) and one discrete trait (SPENT). Evidence of mitochondrial contribution was found for one discrete trait (CRAVING) and three continuous traits (ln(CIGPKYR), ecb21, and tth1). Results for ntth1 suggest that methods that do not also allow for male-female heterogeneity in environmental variance may be overly conservative in detection of X-chromosomal effects.
我们报告了一种简单而快速的方法，用于在缺乏该染色体标记数据的情况下检测 X 连锁基因座的加性遗传方差。我们研究了这种方法与一种已建立的检测线粒体连锁的方法（另一个性别不对称遗传协方差的来源）的相互作用。当应用于来自酒精遗传合作研究的数据时，该方法发现了一个连续性状（ntth1）和一个离散性状（SPENT）的 X 染色体连锁的证据。线粒体贡献的证据被发现存在于一个离散性状（CRAVING）和三个连续性状（ln(CIGPKYR)、ecb21 和 tth1）中。ntth1 的结果表明，那些不允许环境方差在男性和女性之间存在异质性的方法，在检测 X 染色体效应时可能过于保守。
