Department of Epidemiology, Unit 1340, University of Texas M. D. Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S161. doi: 10.1186/1471-2156-6-S1-S161.
Genomic imprinting, which is also known as the parent-of-origin effect, is a mechanism that only expresses one copy of a gene pair depending upon the parental origin. Although many chromosomal regions in the human genome are likely to be imprinted, imprinting is not accounted for in the usual linkage analysis. In this study, using a variance-components approach with a quantitative phenotype ttth-FP1, we found significant evidence of imprinting at two loci, D7S1790 and D1S1631, on chromosome 1 and chromosome 7, respectively. Our results suggest that allowing for the possibility of imprinting can increase the power to detect linkage for localizing genes for alcoholism.
基因组印记，也称为亲本来源效应，是一种仅根据亲本来源表达基因对的一个副本的机制。尽管人类基因组中的许多染色体区域可能被印记，但印记在通常的连锁分析中并不考虑。在这项研究中，我们使用具有定量表型 ttth-FP1 的方差分量方法，在 1 号染色体和 7 号染色体上的 D7S1790 和 D1S1631 两个基因座上发现了印记的显著证据。我们的研究结果表明，考虑到印记的可能性可以提高检测酗酒基因定位的连锁能力。
