COGA 家系中重组率的方差成分分析。
A variance component analysis on recombination rate in the COGA pedigrees.
机构信息
Population for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S58. doi: 10.1186/1471-2156-6-S1-S58.
We estimated the crossover frequency in 1,232 gametes from 356 subjects in pedigrees from the Collaborative Study on the Genetics on Alcoholism. We examined the effect of covariates including age, ethnicity, and years with ALDX1 on recombination rate, and found a positive correlation between recombination rate and years with ALDX1. By variance-component analysis, we estimated the heritability of recombination rate to be around 0.5, and provided suggestive evidence for a locus linked to recombination rate.
我们在 356 名个体的家系中估计了 1232 个配子的交叉频率，这些个体来自酒精中毒遗传学合作研究。我们研究了包括年龄、种族和 ALDX1 年数在内的协变量对重组率的影响，发现重组率与 ALDX1 年数呈正相关。通过方差成分分析，我们估计重组率的遗传力约为 0.5，并提供了与重组率相关的连锁位点的提示性证据。
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