Modeling and Methods, Biostatistics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S60. doi: 10.1186/1471-2156-6-S1-S60.
The transmission/disequilibrium test statistic has been used for assessing genetic association in affected-parent trios. In the presence of multiple tightly linked marker loci where local dependency may exist, haplotypes are reconstructed statistically to estimate the joint effects of these markers. In this manuscript, we propose an alternative to the haplotype approach by taking a weighted average of multiple loci, where the weight is proportional to the product of (1-2X recombination fraction) and the linkage disequilibrium between markers. As an illustration, we applied the method to the simulated Aipotu data.
传递/不平衡检验统计量已被用于评估受影响父母三体型中的遗传关联。在多个紧密连锁的标记位点存在局部依赖性的情况下，通过统计重建单倍型来估计这些标记的联合效应。在本文中，我们提出了一种替代单倍型方法的方法，通过对多个位点进行加权平均，其中权重与（1-2X 重组分数）与标记之间的连锁不平衡的乘积成正比。作为说明，我们将该方法应用于模拟的 Aipotu 数据。
