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金黄色葡萄球菌对过氧化氢反应的全转录组分析

Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide.

作者信息

Chang Wook, Small David A, Toghrol Freshteh, Bentley William E

机构信息

Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park 20742, USA.

出版信息

J Bacteriol. 2006 Feb;188(4):1648-59. doi: 10.1128/JB.188.4.1648-1659.2006.

Abstract

Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.

摘要

金黄色葡萄球菌会采取针对吞噬细胞衍生的活性氧化剂的保护策略来感染人类。在此,我们报告了金黄色葡萄球菌对过氧化氢诱导的氧化应激的细胞反应的转录组分析。数据表明,氧化反应包括诱导参与毒力、DNA修复以及尤其是无氧代谢的基因。

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