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SOS 反应：激活、影响及药物靶点。

SOS response: Activation, impact, and drug targets.

作者信息

Cheng Kaiying, Sun Yukang, Yu Huan, Hu Yingxuan, He Yini, Shen Yuanyuan

机构信息

Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University Hangzhou Normal University Hangzhou China.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China.

出版信息

mLife. 2024 Sep 30;3(3):343-366. doi: 10.1002/mlf2.12137. eCollection 2024 Sep.

DOI:10.1002/mlf2.12137
PMID:39359682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11442139/
Abstract

is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic-resistant strains and small colony variants. This surge presents a significant challenge in eliminating infections and undermines the efficacy of available treatments. The bacterial Save Our Souls (SOS) response, triggered by genotoxic stressors, encompasses host immune defenses and antibiotics, playing a crucial role in bacterial survival, invasiveness, virulence, and drug resistance. Accumulating evidence underscores the pivotal role of the SOS response system in the pathogenicity of . Inhibiting this system offers a promising approach for effective bactericidal treatments and curbing the evolution of antimicrobial resistance. Here, we provide a comprehensive review of the activation, impact, and key proteins associated with the SOS response in . Additionally, perspectives on therapeutic strategies targeting the SOS response for , both individually and in combination with traditional antibiotics are proposed.

摘要

是多种感染的常见原因，从浅表感染到侵袭性感染，影响人类和动物。临床治疗中抗生素的广泛使用导致了抗生素耐药菌株和小菌落变体的出现。这种激增在消除感染方面带来了重大挑战，并削弱了现有治疗方法的疗效。由基因毒性应激源触发的细菌“拯救我们的灵魂”（SOS）反应包括宿主免疫防御和抗生素，在细菌的存活、侵袭性、毒力和耐药性中起着关键作用。越来越多的证据强调了SOS反应系统在……致病性中的关键作用。抑制该系统为有效的杀菌治疗和遏制抗菌药物耐药性的演变提供了一种有前景的方法。在这里，我们全面综述了与……中SOS反应相关的激活、影响和关键蛋白。此外，还提出了针对……的SOS反应的治疗策略的观点，包括单独使用以及与传统抗生素联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/0e6b73cb9466/MLF2-3-343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/7e61d747628b/MLF2-3-343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/2a09ef8f0c46/MLF2-3-343-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/32542629946d/MLF2-3-343-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/a163059581d2/MLF2-3-343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/ddacd3ab902e/MLF2-3-343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/4785ae107c02/MLF2-3-343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/0e6b73cb9466/MLF2-3-343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/7e61d747628b/MLF2-3-343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/2a09ef8f0c46/MLF2-3-343-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/32542629946d/MLF2-3-343-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/a163059581d2/MLF2-3-343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/ddacd3ab902e/MLF2-3-343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/4785ae107c02/MLF2-3-343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5c1/11442139/0e6b73cb9466/MLF2-3-343-g003.jpg

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